The Recent Emergence of Clostridium difficile Infection in Romanian Hospitals is Associated with a High Prevalence of Polymerase Chain Reaction Ribotype 027
| Autor: | Dragoş Florea, Andreea Niculcea, Alexandru Rafila, Daniela Lemeni, Adriana Pistol, Andreea Preda, Ioana Sabina Macovei, Roxana Serban, Daniela Tălăpan, Gabriel Adrian Popescu |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
ribotype 027 medicine.medical_specialty 030106 microbiology lcsh:Medicine law.invention 03 medical and health sciences Minimum inhibitory concentration Ribotyping Moxifloxacin law Internal medicine Epidemiology Infection control Medicine Polymerase chain reaction Clostridium difficile epidemiology ribotype 027 Romania business.industry Romania lcsh:R General Medicine Clostridium difficile Clostridium difficile infections epidemiology business medicine.drug |
| Zdroj: | Balkan Medical Journal, Vol 35, Iss 2, Pp 191-195 (2018) Volume: 35, Issue: 2 191-195 Balkan Medical Journal |
| ISSN: | 2146-3131 2146-3123 |
| Popis: | Aims: To investigate the epidemiology of Clostridium difficile infection in Romanian hospitals.Methods: A survey was conducted at nine hospitals throughout Romania between November 2013 and February 2014.Results: The survey identified 393 patients with Clostridium difficile infection. The median age was 67 years (range: 2-94 years); 56% of patients were aged >65 years. The mean prevalence of Clostridium difficile infection was 5.2 cases per 10.000 patient-days. The highest prevalences were 24.9 and 20 per 10.000 patient-days in hospitals specializing in gastroenterology and infectious diseases, respectively. Clostridium difficile infections were health care-associated in 70.5% patients and community-acquired in 10.2%. The origin was not determined in 19.3%. Clostridium difficile infection was severe in 12.3% of patients, and the in-hospital all-cause mortality was 8.8%. Polymerase chain reaction ribotype 027 had the highest prevalence in all participating hospitals and represented 82.6% of the total ribotyped isolates. The minimum inhibitory concentration of moxifloxacin was >4 μg/mL for 59 of 80 tested isolates (73.8%). Of 59 isolates, 54 were highly resistant to moxifloxacin (minimum inhibitory concentration ≥32 μg/mL), and the majority were polymerase chain reaction ribotype 027 (p |
| Databáze: | OpenAIRE |
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