NT-proBNP and BNP values in cardiac patients with different degree of left ventricular systolic dysfunction
| Autor: | Milada Halacova, Jana Popelová, Jiri Bronsky, Richard Prusa, Jiri Kukacka, Marie Tiserova, Karel Kotaska, Peter Telekes, Marie Vrzanova |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease medicine.drug_class Cardiomyopathy General Biochemistry Genetics and Molecular Biology Coronary artery disease Ventricular Dysfunction Left Internal medicine Natriuretic Peptide Brain Natriuretic peptide Medicine Humans cardiovascular diseases Aged Ejection fraction Receiver operating characteristic business.industry Stroke Volume Stroke volume Middle Aged medicine.disease Peptide Fragments Heart failure cardiovascular system Cardiology Female business hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 150(1) |
| ISSN: | 1213-8118 |
| Popis: | We investigated the performance of brain natriuretic peptides (BNP and NT-proBNP) in detecting various degrees of left ventricular systolic dysfunction. The NT-proBNP assay (Roche) and the BNP assay (Bayer Shionoria) were performed in 46 patients (mean age 50 years; range 20-79 years) with various types of heart disease (chronic heart failure due to coronary artery disease, cardiomyopathy, acquired valve disease, congenital heart diseases) and different impairment of left ventricular systolic dysfunction was assessed by echocardiography. Patients were divided into four groups according to the left ventricular ejection fraction (LVEF) correlated with clinical severity. Significant differences in medians of NT-proBNP and BNP values between all groups were determined (P= 0.0161 for NT-proBNP and P=0.0180 for BNP). For identifying patients with severe systolic dysfunction (LVEF |
| Databáze: | OpenAIRE |
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