Leishmania tropica infection, in comparison to Leishmania major, induces lower delayed type hypersensitivity in BALB/c mice
| Autor: | Simin Sadat Kiaei, Davood Iravani, Hamid Mahmoudzadeh-Niknam |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Leishmania tropica
Leishmaniasis Cutaneous Biology BALB/c Mice Antigen Cutaneous leishmaniasis parasitic diseases medicine Animals Hypersensitivity Delayed Leishmania major Sensitization Mice Inbred BALB C Foot Ear Leishmaniasis medicine.disease biology.organism_classification Leishmania Disease Models Animal medicine.anatomical_structure Immunology Female Original Article |
| Zdroj: | The Korean Journal of Parasitology. 45:103 |
| ISSN: | 0023-4001 |
| DOI: | 10.3347/kjp.2007.45.2.103 |
| Popis: | Leishmania tropica and L. major are etiologic agents of human cutaneous leishmaniasis. Delayed type hypersensitivity (DTH) is an immunologic response that has been frequently used as a correlate for protection against or sensitization to leishmania antigen. In BALB/c mice, L. tropica infection results in non-ulcerating disease, whereas L. major infection results in destructive lesions. In order to clarify the immunologic mechanisms of these 2 different outcomes, we compared the ability of these 2 leishmania species in induction of DTH response in this murine model. BALB/c mice were infected with L. major or L. tropica, and disease evolution and DTH responses were determined. The results show that the primary L. major infection can exacerbate the secondary L. major infection and is associated with DTH response. Higher doses of the primary L. major infection result in more disease exacerbation of the secondary L. major infection as well as higher DTH response. L. tropica infection induces lower DTH responses than L. major. We have previously reported that the primary L. tropica infection induces partial protection against the secondary L. major infection in BALB/c mice. Induction of lower DTH response by L. tropica suggests that the protection induced against L. major by prior L. tropica infection may be due to suppression of DTH response. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|