Ouabain-induced seizures in rats: modification by melatonin and melanocyte-stimulating hormone
| Autor: | André Barbeau, K. Izumi, J. Donaldson, Minnich Jl |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
endocrine system
medicine.medical_specialty Melanocyte-stimulating hormone Time Factors Physiology Heart Ventricles Biology Tritium Ouabain Cerebral Ventricles Injections Melatonin Seizures Physiology (medical) Internal medicine medicine Animals Melanocyte-Stimulating Hormones Pharmacology Brain General Medicine Rats Endocrinology Female hormones hormone substitutes and hormone antagonists medicine.drug Hormone |
| Zdroj: | Canadian journal of physiology and pharmacology. 51(8) |
| ISSN: | 0008-4212 |
| Popis: | The effects of melatonin and synthetic alpha-melanocyte-stimulating hormone (MSH) on ouabain-induced seizures in experimental animals were determined. Fifteen micrograms of melatonin or ten micrograms of α-MSH (dissolved in 2% ethanol – 0.85% saline) were administered intraventricularly to young female rats. The administration of melatonin was found to provide a protective effect against the seizures. The maximum suppressive effect against ouabain seizures was obtained when melatonin was given 1 min prior to the injection of ouabain. In contrast, the injection of α-MSH aggravated seizure activity elicited by 3 μg of ouabain.During experiments designed to determine the regional distribution in the brain of intraventricularly administered 3H-melatonin, high accumulation of the radioactive compound was found in the medulla oblongata – pons, the hypothalamus, and the hippocampus. The lowest activity was in the cerebral cortex. |
| Databáze: | OpenAIRE |
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