Hemodialysis Clearance of Encainide and Metabolites
| Autor: | Halstenson Ce, Halvorsen Mb, Whitmer Jt |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Oral dose medicine.medical_specialty Encainide medicine.medical_treatment Metabolite Urology Renal function chemistry.chemical_compound Pharmacokinetics Renal Dialysis Oral administration Internal medicine medicine Humans Pharmacology (medical) Hemodialysis Clearance Pharmacology business.industry Endocrinology chemistry Kidney Failure Chronic Hemodialysis business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | Therapeutic Drug Monitoring. 13:375-378 |
| ISSN: | 0163-4356 |
| DOI: | 10.1097/00007691-199107000-00016 |
| Popis: | The disposition of encainide and metabolites O-desmethylencainide (ODE) and 3-methyl-ODE (MODE) was evaluated in a 31-year-old hemodialysis patient following a 25 mg oral dose during an interdialytic period and a second 25 mg oral dose 48 h later, 2 h before a hemodialysis procedure. The inter- and intradialytic elimination half-lives were not different for encainide and its metabolites ODE and MODE. The hemodialysis clearance of encainide, MODE, and ODE are all less than 10% of the creatinine clearance of the dialyzer. Thus, hemodialysis does not result in clinically significant removal of encainide or its metabolites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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