Magnetic resonance guided renal denervation using active tracking: first in vivo experience in Swine
| Autor: | Malte Kelm, C Meyer, Bernhard Schnackenburg, Sascha Krüger, Steffen Weiss, Florian Bönner, Sebastian M. Haberkorn, Mirja Neizel-Wittke, P. Behm |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Sympathetic Nervous System Time Factors Swine Interventional magnetic resonance imaging Biopsy Perforation (oil well) 030204 cardiovascular system & hematology Kidney Magnetic Resonance Imaging Interventional 030218 nuclear medicine & medical imaging 03 medical and health sciences Renal Artery 0302 clinical medicine medicine.artery Image Interpretation Computer-Assisted medicine Animals Radiology Nuclear Medicine and imaging Sympathectomy Renal artery Cardiac imaging Denervation medicine.diagnostic_test business.industry Magnetic resonance imaging Renal sympathetic denervation Models Animal Angiography Catheter Ablation Feasibility Studies Swine Miniature Radiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | The International Journal of Cardiovascular Imaging. 34:431-439 |
| ISSN: | 1573-0743 1569-5794 |
| Popis: | Interventional cardiovascular magnetic resonance (iCMR) might evolve as a technique to improve procedural success rates in cardiovascular interventions by combining intraprocedural guidance and simultaneous lesion imaging. The objective of the present study was to prove feasibility and estimate safety of renal sympathetic denervation guided by real-time iCMR using active tracking. Six pigs were examined in a 1.5 T MRI-System (Achieva, Philips Healthcare, Best, Netherlands) equipped with non-invasive hemodynamic control and in-room monitors displaying an interventional software platform [Interventional MRI Suite (iSuite), Philips Research, Hamburg, Germany]. MR-guided renal denervation was performed using a MR conditional non-irrigated ablation catheter with active tracking (Imricor, Burnsville, MN, USA). Real-time imaging for device guidance was performed with a TFE sequence, vessel patency was assessed with a 3D non-contrast angiography and velocity encoded imaging. Oedema of the renal artery was visualized by a high-resolution T2 SPIR sequence. Renal sympathetic denervation was feasible in all cases with survival of all animals. Non-contrast angiography displayed renal artery patency accompanied by equal flow conditions before and after the ablation in all cases as measured by velocity encoded imaging. Oedema imaging displayed a significant increase in relative signal intensity at renal artery ablations sites pre and post intervention (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink