Oesophageal transit in patients with autonomic dysfunction. The effect of treatment with fludrocortisone
| Autor: | F. Boesen, Andersen Eb, F. Jørgensen, Birger Hesse |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Atropine Male medicine.medical_specialty Time Factors Physiology Fludrocortisone Gastroenterology Hypotension Orthostatic Orthostatic vital signs Esophagus Diabetic Neuropathies Internal medicine Diabetes mellitus Heart rate medicine Humans Gastrointestinal Transit Radionuclide Imaging Aged Sodium Pertechnetate Tc 99m business.industry Fludrocortisone Acetate Parkinson Disease General Medicine Middle Aged medicine.disease Pathophysiology medicine.anatomical_structure Endocrinology Autonomic Nervous System Diseases Female business medicine.drug |
| Zdroj: | Clinical Physiology. 11:83-92 |
| ISSN: | 1365-2281 0144-5979 |
| DOI: | 10.1111/j.1475-097x.1991.tb00656.x |
| Popis: | Oesophageal function was examined by radionuclide transit measurements in 15 patients with severe autonomic deficiency and orthostatic hypothension and 23 healthy volunteers. Seven of the patients were re-examined after treatment for 3 weeks with fludrocortisone acetate (Florinef). Six patients and five control subjects were evaluated before and after i.v. administration of atropine. The mean transit time (MTT) was prolonged (P less than 0.007) and the residual activity increased (P = 0.038) in the patients compared with the control group. Prolonged MTT was associated with oesophageal symptoms. Treatment of orthostatic hypotension with fludrocortisone acetate significantly reduced MTT. Atropine increased MTT and residual activity. The increase in heart rate after atropine was correlated in the patients with MTT before treatment. The results demonstrate the frequent presence of impaired oesophageal function in patients with severe autonomic dysfunction, irrespective of aetiology. The impairment seems to be closely related to parasympathetic insufficiency. The improvement after fludrocortisone may suggest an influence of ion balance on oesophageal function in these patients. |
| Databáze: | OpenAIRE |
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