Cystic fibrosis dyslipidaemia: A cross-sectional study
| Autor: | Aleksandra Lisowska, Edyta Mądry, Andrzej Pogorzelski, Sławomira Drzymała-Czyż, Mariusz Szczepanik, Jarosław Walkowiak, Ewa Sapiejka, Irena Wojsyk-Banaszak, Jan Krzysztof Nowak, Anna Miśkiewicz-Chotnicka, Agata Nowicka, Patrycja Krzyżanowska-Jankowska, Andrzej Wykretowicz, Wojciech Skorupa |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine Apolipoprotein E medicine.medical_specialty Malabsorption Cystic Fibrosis Cross-sectional study Disease Cystic fibrosis Gastroenterology Young Adult 03 medical and health sciences Apolipoproteins E 0302 clinical medicine Internal medicine medicine Humans Correlation of Data Dyslipidemias Adiponectin medicine.diagnostic_test business.industry nutritional and metabolic diseases medicine.disease Lipoproteins LDL Cross-Sectional Studies 030104 developmental biology 030228 respiratory system Pediatrics Perinatology and Child Health Female lipids (amino acids peptides and proteins) Lipid profile business Lipoprotein |
| Zdroj: | National Information Processing Institute |
| ISSN: | 1569-1993 |
| DOI: | 10.1016/j.jcf.2019.04.001 |
| Popis: | Background The interest in cystic fibrosis (CF) dyslipidaemia as a potential risk factor for cardiovascular disease is increasing with patients' survival. This study aimed to investigate CF dyslipidaemia, its clinical correlates and links to oxidized low-density lipoprotein (oxLDL), adiponectin, and apolipoprotein E (APOE). Methods This cross-sectional study assessed clinical characteristics of CF, as well as the serum lipid profile, oxLDL, adiponectin, and APOE. Results In total, 108 CF subjects were enrolled in this study, with a median age of 22 years, BMI of 20.5 kg/m2, FEV1% of 61%, of which 81% were pancreatic insufficient (PI). Healthy subjects (HS; n = 51) were in similar age. Hypocholesterolaemia occurred in 31% of CF subjects and in no HS. Hypertriglyceridaemia concerned 21% of patients (HS: 8%, p = .04), and low HDL-C 45% (HS: 6%, p Conclusions CF dyslipidaemia is highly prevalent and heterogenous. The lipid profile weakly associates with the clinical characteristics of CF as well as oxLDL, adiponectin, and APOE. Further research is needed, especially regarding HDL function in CF, the causes of hypertriglyceridaemia, and the value of essential fatty acid supplementation for CF dyslipidaemia. |
| Databáze: | OpenAIRE |
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