Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation

Autor:	Tatsushi Osawa, Masaharu Ishikawa, Toyoo Nakao, Hiroshi Iijima, Kaname Kimura, Junko Ito, Hiroyuki Kawai, Akihiro Ueno, Hiroshi Ohashi
Rok vydání:	1999
Předmět:	Stereochemistry Metabolite Clinical Biochemistry Substituent Pharmaceutical Science Benzoates Biochemistry Chemical synthesis Cell Degranulation Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Anti-Allergic Agents mental disorders Drug Discovery medicine Humans Eosinophil degranulation Phenols Molecular Biology integumentary system Chemistry organic chemicals Organic Chemistry Degranulation Hydrogen Bonding Eosinophil In vitro Eosinophils medicine.anatomical_structure Molecular Medicine psychological phenomena and processes
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 9:1945-1948
ISSN:	0960-894X
Popis:	Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfe195697d9be66d3d1994dd135b506 https://doi.org/10.1016/s0960-894x(99)00305-4 Zobrazit plný text záznamu Full Text from ScienceDirect