A Distinct Class of Bursting Neurons with Strong Gamma Synchronization and Stimulus Selectivity in Monkey V1
| Autor: | Irene Onorato, Sergio Neuenschwander, Jennifer L. Hoy, Georgios Spyropoulos, Martin Vinck, Thilo Womelsdorf, Cem Uran, Katia-Simone Rocha, Johanna Klon-Lipok, Cristopher M. Niell, Wolf Singer, Ana Clara Broggini, Pascal Fries, Bruss Lima |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine cell class Cell type orientation tuning Cebinae Interneuron Action Potentials interneuron Stimulus (physiology) Biology Inhibitory postsynaptic potential Mice 03 medical and health sciences Bursting 0302 clinical medicine Rhythmic inhibition Gamma Rhythm medicine Animals excitatory Cortical Synchronization monkey V1 Visual Cortex Neurons General Neuroscience Neural Inhibition cell type Macaca mulatta 030104 developmental biology medicine.anatomical_structure nervous system Excitatory postsynaptic potential Conditioning Operant Female gamma oscillation Neuroscience Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Neuron Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2019.09.039 |
| Popis: | Cortical computation depends on interactions between excitatory and inhibitory neurons. The contributions of distinct neuron types to sensory processing and network synchronization in primate visual cortex remain largely undetermined. We show that in awake monkey V1, there exists a distinct cell type (››30% of neurons) that has narrow-waveform (NW) action potentials and high spontaneous discharge rates and fires in high-frequency bursts. These neurons are more stimulus selective and phase locked to 30- to 80-Hz gamma oscillations than other neuron types. Unlike other neuron types, their gamma-phase locking is highly predictive of orientation tuning. We find evidence for strong rhythmic inhibition in these neurons, suggesting that they interact with interneurons to act as excitatory pacemakers for the V1 gamma rhythm. We did not find a similar class of NW bursting neurons in L2-L4 of mouse V1. Given its properties, this class of NW bursting neurons should be pivotal for the encoding and transmission of stimulus information. |
| Databáze: | OpenAIRE |
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