Exogenous tumor necrosis factor alpha and interleukin-1 alpha increase resistance to Salmonella typhimurium: efficacy is influenced by the Ity and Lps loci
| Autor: | K Charrier, S N Vogel, P J Morrissey |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Salmonella typhimurium
Salmonella Mice Inbred A Ratón medicine.medical_treatment Immunology Alpha (ethology) medicine.disease_cause Microbiology Mice medicine Animals Mice Inbred C3H Salmonella Infections Animal biology Tumor Necrosis Factor-alpha Macrophages Interleukin Immunotherapy biology.organism_classification Enterobacteriaceae Mice Inbred C57BL Infectious Diseases Cytokine Female Parasitology Tumor necrosis factor alpha Interleukin-1 Research Article |
| Zdroj: | Infection and Immunity. 63:3196-3198 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.63.8.3196-3198.1995 |
| Popis: | Interleukin-1 alpha (IL-1 alpha) or tumor necrosis factor alpha (TNF-alpha) administered prior to infection with Salmonella typhimurium increases survival in mice that are Ityr, not in susceptible Lpsd or Itys mice. Combined IL-1 alpha and TNF-alpha pretreatment results in greater survival than that seen with either cytokine alone in Ityr mice. Treatment after infection with TNF-alpha and/or IL-1 alpha increases the mean time to death but not the survival fraction of Lpsd mice and was ineffective in either Ityr or Itys mice. |
| Databáze: | OpenAIRE |
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