Sensibilidad a IGF-I en niños pequeños para la edad gestacional

Autor: Verónica Mericq G, Ronald D. Gunn, Rossana Román R, Germán Iñiguez, Ariel Fuentes G., Alvaro Barrera P, Fernando Cassorla G, Teresa Salazar C., Alejandra Avila A
Rok vydání: 2006
Předmět:
Zdroj: Revista médica de Chile v.134 n.1 2006
SciELO Chile
CONICYT Chile
instacron:CONICYT
ISSN: 0034-9887
DOI: 10.4067/s0034-98872006000100003
Popis: Background: The lack of catch up growth (CUG) in small for gestational age (SGA) children may be related to a reduced sensitivity to insulin growth factor 1 (IGF-I). Aim: To assess the sensitivity to IGF-I in small for gestational age children, measuring basal and post IGF-I nocturnal profile of growth hormone (GH). Patients and methods: We studied 34 prepubertal SGA children aged 4 to 11 years. Twenty three had CUG and 11 did not have CUG. As an IGF-I sensitivity test, nocturnal GH levels were measured every 20 minutes from 23:00 h to 07:00 h, both under baseline conditions and after the administration of a subcutaneous bolus of 1 mg/kg/body weight of the IGF-I + IGFBP-3 complex (Somatokine®). Results: At the time of the study, the Z scores for height among children with and without CUG were -1.55 ± 0.22 and -3.24 ± 0.28, respectively (p
Databáze: OpenAIRE