Sensibilidad a IGF-I en niños pequeños para la edad gestacional
Autor: | Verónica Mericq G, Ronald D. Gunn, Rossana Román R, Germán Iñiguez, Ariel Fuentes G., Alvaro Barrera P, Fernando Cassorla G, Teresa Salazar C., Alejandra Avila A |
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Rok vydání: | 2006 |
Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty Human growth hormone business.industry Body height Infant SomatoKine Insulin-like growth factor I General Medicine Growth hormone Body weight Infant newborn small for gestational age Bolus (medicine) Endocrinology Sensitivity test Internal medicine medicine business |
Zdroj: | Revista médica de Chile v.134 n.1 2006 SciELO Chile CONICYT Chile instacron:CONICYT |
ISSN: | 0034-9887 |
DOI: | 10.4067/s0034-98872006000100003 |
Popis: | Background: The lack of catch up growth (CUG) in small for gestational age (SGA) children may be related to a reduced sensitivity to insulin growth factor 1 (IGF-I). Aim: To assess the sensitivity to IGF-I in small for gestational age children, measuring basal and post IGF-I nocturnal profile of growth hormone (GH). Patients and methods: We studied 34 prepubertal SGA children aged 4 to 11 years. Twenty three had CUG and 11 did not have CUG. As an IGF-I sensitivity test, nocturnal GH levels were measured every 20 minutes from 23:00 h to 07:00 h, both under baseline conditions and after the administration of a subcutaneous bolus of 1 mg/kg/body weight of the IGF-I + IGFBP-3 complex (Somatokine®). Results: At the time of the study, the Z scores for height among children with and without CUG were -1.55 ± 0.22 and -3.24 ± 0.28, respectively (p |
Databáze: | OpenAIRE |
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