Surgical site infection by carbapenemase-producing Enterobacteriaceae. A challenge for today's surgeons
| Autor: | Ines Rubio-Perez, Rocío Maqueda González, Ismael Mora-Guzmán, Elena Martín-Pérez, Diego Domingo Garcia |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Tigecycline Meropenem Statistics Nonparametric Internal medicine medicine Humans Surgical Wound Infection Digestive System Surgical Procedures Cross Infection Chi-Square Distribution business.industry Septic shock Mortality rate General Engineering Enterobacteriaceae Infections Health Care Costs Middle Aged medicine.disease Colorectal surgery Anti-Bacterial Agents Hospitalization Klebsiella pneumoniae Carbapenem-Resistant Enterobacteriaceae Amikacin Colistin Intraabdominal Infections Female business Abdominal surgery medicine.drug |
| Zdroj: | Cirugia espanola. 98(6) |
| ISSN: | 2173-5077 |
| Popis: | Introduction Infections caused by carbapenemase-producing Enterobacteriaceae (CPE) are dramatically increasing worldwide, with an important impact on surgical patients. Our aim was to assess the clinical profile, outcomes, treatment, mortality and costs of CPE-related surgical site infection (SSI) in patients with abdominal surgery. Methods Review of CPE-related SSI in patients with abdominal surgery from January 2013 to December 2018. Patient factors and interventions present previously to the SSI identification were recorded, and a mortality analysis was also performed in patients with abdominal surgery and CPE-related organ/space SSI. Results Fifty patients were included: superficial incisional SSI 50%, deep incisional SSI 28%, organ/space SSI (or intra-abdominal infection) 70%. Klebsiella pneumoniae OXA-48 was present in 84%, and the most frequent were colorectal surgery (40%) and pancreatic surgery (20%). The antimicrobial susceptibility was: ceftazidime–avibactam 100%, amikacin 91.7%, tigecycline 89.1%, colistin 70.8%, meropenem 62.8%, and imipenem 52.1%. An appropriate definitive antimicrobial treatment was administered in 86%, using a combined scheme in 76%. Global 30-day mortality rate for intra-abdominal infection was 20%, and mortality-related factors were: solid tumor (P=.009), solid metastasis (P=.009), septic shock (P=.02), and blood transfusions (P=.03). Median global stay was 45 (IQR 26–67) days. Median global cost of hospitalization was €29 946 (IQR 15 405–47 749). Conclusions The clinical profile of patients with CPE-related SSI associates several comorbidities, interventions, prolonged stay and elevated costs. Mortality-related factors in intra-abdominal infection are solid tumor, metastasis, septic shock or blood transfusions. |
| Databáze: | OpenAIRE |
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