New Antimicrobial Nitrofuran, trans -5-Amino-3-[2-(5-Nitro-2-Furyl)Vinyl]-Δ 2 -1,2,4-Oxadiazole: Antimicrobial Efficacy in Mice, Rats, and Guinea pigs
| Autor: | R. J. McRipley, R. Semar, Hans H. Gadebusch, Felix Pansy |
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| Rok vydání: | 1974 |
| Předmět: |
Male
medicine.drug_class Guinea Pigs Antibiotics 5-Amino-3-((5-nitro-2-furyl)vinyl)-1 2 4-oxadiazole Infections Microbiology Mice Shigella flexneri Anti-Infective Agents medicine Animals Dermatomycoses Candicidin Pharmacology (medical) Candida albicans Nitrofuran Pharmacology biology Articles Vaginosis Bacterial biology.organism_classification Antimicrobial Proteus mirabilis Rats Infectious Diseases Nystatin Female Trichomonas Vaginitis medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 6:268-273 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | A new antimicrobial nitrofuran designated SQ 18,506 showed some therapeutic activity when administered orally to mice infected with Escherichia coli, Salmonella schottmuelleri, Shigella flexneri , or Klebsiella pneumoniae . Animals infected parenterally with Streptococcus pyogenes, Proteus mirabilis, Mycobacterium tuberculosis , and Candida albicans , or topically with Trichophyton mentagrophytes , did not respond to therapy with the drug at the dosage levels used. The compound was as effective as metronidazole in the topical treatment of experimental trichomonal infections in mice and in guinea pigs and as effective as nystatin, candicidin, or a sulfanilamide-aminacrine hydrochloride cream in the treatment of a candidal vaginal infection in rats. The chemotherapeutic efficacy of SQ 18,506 in experimental vaginitis caused by Escherichia coli in the rat surpassed that shown by four commercial products available for the treatment of bacterial vaginitis. |
| Databáze: | OpenAIRE |
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