Antibiotic Treatment Does Not Ameliorate the Metabolic Changes in Rats Presenting Dysbiosis After Consuming a High Fructose Diet
| Autor: | Katya Sosnovski, Avshalom Leibowitz, Yael Haberman, Ariel Bier, Amnon Amir, Ehud Grossman, Rawan Khasbab, Tzipi Braun, Rotem Hadar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty microbiome lcsh:TX341-641 Article metabolic syndrome fructose Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine Animals 030109 nutrition & dietetics Nutrition and Dietetics Triglyceride Fatty liver Fructose Metabolism dysbiosis Fructose transport medicine.disease Anti-Bacterial Agents Diet Gastrointestinal Microbiome Rats 030104 developmental biology Endocrinology Liver chemistry Lipogenesis Metabolic syndrome Dysbiosis lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 12, Iss 1, p 203 (2020) Nutrients Volume 12 Issue 1 |
| ISSN: | 2072-6643 |
| Popis: | High fructose consumption is one of the hallmarks of Western diets and has been found to induce MeS symptoms in parallel to gut microbial dysbiosis. However, the causality between those two is still elusive. Here, we studied whether a significant modification of gut microbial composition by antibiotics can influence the fructose-induced metabolic changes. Male Sprague-Dawley (SD) rats were divided into four groups including controls, controls + antibiotics, high fructose diet (HFrD, 60% fructose), HFrD + antibiotics (n = 7&ndash 8 in each group) for a period of 8-weeks. The high fructose diet increased blood pressure (BP), triglyceride (TG), fatty liver and the expression of hepatic genes related to lipogenesis, and fructose transport and metabolism. In addition, fructose changed the microbial composition and increased acetic and butyric acids in fecal samples but not in the blood. Antibiotic treatment significantly reduced microbial diversity and modified the microbial composition in the samples. However, minimal or no effect was seen in the metabolic phenotypes. In conclusion, high fructose consumption (60%) induced metabolic changes and dysbiosis in rats. However, antibiotic treatment did not reverse the metabolic phenotype. Therefore, the metabolic changes are probably independent of a specific microbiome profile. |
| Databáze: | OpenAIRE |
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