APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

Autor: Aldona Dembinska-Kiec, Andrew L. Carvalho-Wells, Audrey C. Tierney, Christian A. Drevon, Rosalind Fallaize, Ellen E. Blaak, Julie A. Lovegrove, Carmen Marin, Helen M. Roche, Beata Kieć-Wilk, Ulf Risérus, Catherine Defoort, Wim H. M. Saris, Jose Lopez-Miranda
Přispěvatelé: RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - HB/BW section A, RS: NUTRIM - R1 - Metabolic Syndrome
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Apolipoprotein E
Male
Apolipoprotein B
GENE-DIET INTERACTION
030204 cardiovascular system & hematology
0302 clinical medicine
chemistry.chemical_classification
Metabolic Syndrome
Nutrition and Dietetics
Multidisciplinary
biology
Fatty Acids
Middle Aged
Lipids
C-REACTIVE PROTEIN
Näringslära
CARDIOVASCULAR-DISEASE
Medicine
lipids (amino acids
peptides
and proteins)
Female
Polyunsaturated fatty acid
Adult
medicine.medical_specialty
Genotype
Science
Apolipoprotein C-II
Article
Apolipoproteins E
POOLED ANALYSIS
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Humans
CORONARY-HEART-DISEASE
LIPOPROTEIN PHENOTYPE
Aged
Apolipoprotein C-III
Polymorphism
Genetic
business.industry
medicine.disease
E POLYMORPHISM
Diet
CHOLESTEROL RESPONSE
030104 developmental biology
Endocrinology
EUROPEAN POPULATIONS
chemistry
biology.protein
Metabolic syndrome
Insulin Resistance
business
LIPID-LEVELS
Zdroj: Scientific Reports, 7:6274. Nature Publishing Group
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
ISSN: 2045-2322
Popis: Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.
Databáze: OpenAIRE
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