Modulation of Pro-inflammatory and Anti-inflammatory Cytokines in the Fat by an Aloe Gel-based Formula, QDMC, Is Correlated with Altered Gut Microbiota
| Autor: | Jiyeon Kim, Sungwon Lee, Kyungjae Kim, Youngcheon Song, Hyunseok Kong, Jinho An, Heetae Lee, Il Ho Park |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
biology medicine.drug_class Ruminococcus medicine.medical_treatment Immunology Inflammation Gut flora Pharmacology biology.organism_classification Anti-inflammatory Proinflammatory cytokine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Infectious Diseases Cytokine Oral administration medicine Immunology and Allergy medicine.symptom Bacteroides 030215 immunology |
| Zdroj: | Immune Network. 21 |
| ISSN: | 2092-6685 1598-2629 |
| Popis: | Abnormal inflammatory responses are closely associated with intestinal microbial dysbiosis. Oral administration of Qmatrix-diabetes-mellitus complex (QDMC), an Aloe gel-based formula, has been reported to improve inflammation in type 2 diabetic mice; however, the role of the gut microbiota in ameliorating efficacy of QDMC remains unclear. We investigated the effect of QDMC on the gut microbiota in a type 2 diabetic aged mouse model that was administered a high-fat diet. Proinflammatory (TNF-α and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokine levels in the fat were normalized via oral administration of QDMC, and relative abundances of Bacteroides, Butyricimonas, Ruminococcus, and Mucispirillum were simultaneously significantly increased. The abundance of these bacteria was correlated to the expression levels of cytokines. Our findings suggest that the immunomodulatory activity of QDMC is partly mediated by the altered gut microbiota composition. |
| Databáze: | OpenAIRE |
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