Effects of acute hypoxic provocation on the autonomic nervous system in 'healthy' young smokers, measured by heart rate variability
| Autor: | Kiril Terziyski, Peter Dimov, M. Topolov, Blagoi Marinov, Stefan Kostianev, Zdravko Taralov |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Provocation test Signs and symptoms 030204 cardiovascular system & hematology Autonomic Nervous System Autonomic regulation 03 medical and health sciences Young Adult 0302 clinical medicine Heart Rate Risk Factors Internal medicine medicine Heart rate variability Humans Hypoxia Young male Smokers business.industry Smoking Age Factors Heart General Medicine Non-Smokers Hypoxia (medical) Hypoxicator Autonomic nervous system Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular journal of Africa. 30(2) |
| ISSN: | 1680-0745 |
| Popis: | Aim The aim of this study was to compare the activity of the autonomic nervous system (ANS) using heart rate variability (HRV) in 'healthy' young smokers and non-smokers before, during and after exogenous hypoxic provocation. Methods Twenty-one healthy non-smoking males aged 28.0 ± 7.4 years (mean ± SD) and 14 'healthy' smoking males aged 28.1 ± 4.3 years with 9.2 ± 5.6 pack-years were subjected to one-hour hypoxic exposure (FiO2 = 12.3 ± 1.5%) via a hypoxicator. HRV data was derived via Kubios HRV, Finland software by analysing the pre-hypoxic, hypoxic and post-hypoxic periods. Results Standard deviation of the intervals between normal beats (SDNN) was higher in the non-smokers in the pre-hypoxic period (62.0 ± 32.1 vs 40.3 ± 16.2 ms, p = 0.013) but not in the hypoxic period (75.7 ± 34.8 vs 57.9 ± 18.3 ms, p = 0.167). When comparing intra-group HRV changes, shifting from hypoxic to normoxic conditions, there was an increase in the mean square root of successive R-R interval differences (RMSSD) (65.9 ± 40.2 vs 75.1 ± 45.9 ms, p = 0.011), but these changes were observed in only the group of non-smokers. Conclusions Smoking probably impairs autonomic regulation in healthy young males and may lead to decreased HRV, even before subjective clinical signs and symptoms appear. |
| Databáze: | OpenAIRE |
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