The Effect of Statins in Heart Failure: Beyond its Cholesterol-Lowering Effect
| Autor: | Binu Jacob, Jun Chiong, Sunder Sankaran, Prithviraj Rai, Kizhake C. Kurian, Alan B. Miller |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Heart Failure
medicine.medical_specialty biology business.industry Anticholesteremic Agents Cardiomyopathy Inflammation Disease medicine.disease medicine.disease_cause Angiotensin II Cholesterol Heart failure Internal medicine HMG-CoA reductase medicine biology.protein Cardiology Humans Dementia Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom Cardiology and Cardiovascular Medicine business Oxidative stress |
| Zdroj: | Journal of Cardiac Failure. 12:473-478 |
| ISSN: | 1071-9164 |
| DOI: | 10.1016/j.cardfail.2006.02.001 |
| Popis: | Background Statins known as 3-hydroxyl-3-methyl-glutaryl-coenzyme A (HMG-CoA) are designed to lower plasma cholesterol levels. They are used to treat hypercholesterolemia, ischemic heart disease patients, heart transplant recipients, in prevention of Alzheimer's dementia, multiple sclerosis, and have also been shown to reduce cancer risk. Methods and Results The idea of statin treatment in chronic heart failure is not well established. It has been shown to be beneficial in patients with ischemic heart disease with heart failure. Emerging trends show their usefulness in patients with nonischemic heart failure. Statins exhibit pleiotropic effects in stabilizing the atherosclerotic plaques, improvement of endothelial function, inhibition of cell migration and proliferation, and reduction of inflammation and oxidative stress. They also improve autonomic function with an increased parasympathetic drive, downregulate the angiotensin II type I receptors, and induce angiogenesis. Conclusion This article is a review on the current knowledge on statin use in heart failure. |
| Databáze: | OpenAIRE |
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