Influence of Anthropometric Characteristics in Patients With Her2-Positive Breast Cancer on Initial Plasma Concentrations of Trastuzumab
| Autor: | Isaac Ceballos Lenza, Ruth Ramos Díaz, Matías Llabres Martinez, Jonathan González García, José Norberto Batista López, Gloria Julia Nazco Casariego, Fernando Gutiérrez Nicolás |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty Receptor ErbB-2 Breast Neoplasms 03 medical and health sciences Cmin Antineoplastic Agents Immunological 0302 clinical medicine Breast cancer Pharmacokinetics Trastuzumab Internal medicine medicine Humans Pharmacology (medical) Prospective Studies Prospective cohort study Aged Aged 80 and over business.industry Cancer Middle Aged medicine.disease Clinical trial 030104 developmental biology 030220 oncology & carcinogenesis Pharmacodynamics Female business medicine.drug |
| Zdroj: | Annals of Pharmacotherapy. 51:976-980 |
| ISSN: | 1542-6270 1060-0280 |
| DOI: | 10.1177/1060028017715727 |
| Popis: | Background: Plasma concentrations of trastuzumab min) of 20 µg/mL after first drug administration, established as therapeutically effective in clinical trials. The secondary objective was to identify the physiological and anthropometric characteristics that determine interindividual pharmacokinetic variability. Methods: Serum concentrations of trastuzumab were assessed by ELISA on day 1 of the second cycle before administration of the second dose ( Cmin). Results: Of 19 patients included, 9 (47.4%) had a mean Cmin of 19.0 µg/mL (±12.1) after the first administration. Body mass index (BMI) and weight was the main variable that determined the achievement of therapeutic levels after the first administration. Thus, the proportion of patients reaching the target concentration was 89% when BMI was ≤30 kg/m2 but only 11% when BMI was >30 kg/m2 ( P < 0.01). Conclusions: The standard dose of 600 mg subcutaneous trastuzumab did not ensure adequate pharmacodynamic exposure from the first administration in 52% of patients, with weight and BMI being related to the plasma levels obtained. |
| Databáze: | OpenAIRE |
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