Bone morphogenetic protein signaling in inflammation
| Autor: | David H Wu, Antonis K. Hatzopoulos |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Inflammatory arthritis Myocardial Infarction Embryonic Development Inflammation Bone morphogenetic protein General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine medicine Humans Vascular Calcification Vascular inflammation business.industry Arthritis Embryogenesis Anemia medicine.disease Fibrosis Cell biology 030104 developmental biology 030220 oncology & carcinogenesis Bone Morphogenetic Proteins Minireview medicine.symptom business Function (biology) Signal Transduction |
| Zdroj: | Experimental Biology and Medicine. 244:147-156 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | Bone morphogenetic protein signaling has long been established as a crucial pathway during embryonic development. In recent years, our knowledge of the function of bone morphogenetic protein signaling has expanded dramatically beyond solely its important role in development. Today, the pathway is known to have important homeostatic functions across multiple different tissues in the adult. Even more importantly, bone morphogenetic protein signaling is now known to function as a driver of diseases in the adult spanning different organ systems. In this review, we will explore the functions of bone morphogenetic protein signaling in diseases of inflammation. Through this exploration, we will highlight the value and challenges in targeting bone morphogenetic protein signaling for therapeutic interventions.Impact statementBy compiling findings from recent studies, this review will garner novel insight on the dynamic and complex role of BMP signaling in diseases of inflammation, highlighting the specific roles played by both individual ligands and endogenous antagonists. Ultimately, this summary will help inform the high therapeutic value of targeting this pathway for modulating diseases of inflammation. |
| Databáze: | OpenAIRE |
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