Conditioned taste aversion in rats induced by the α1-adrenoceptor agonist cirazoline
| Autor: | Becky T. Davies, Annie Morien, Paul J. Wellman, Lance R. McMahon |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class media_common.quotation_subject Clinical Biochemistry Toxicology Biochemistry Amidephrine Rats Sprague-Dawley Eating Behavioral Neuroscience chemistry.chemical_compound Internal medicine Avoidance Learning medicine Animals Saccharin Biological Psychiatry media_common Pharmacology Dose-Response Relationship Drug Imidazoles Appetite Cirazoline Rats Endocrinology chemistry Taste Anorectic Taste aversion Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-Agonists Phenylpropanolamine medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 48:601-604 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(94)90320-4 |
| Popis: | Recent studies have indicated that α 1 -adrenoceptor agonists such as phenylpropanolamine (PPA), cirazoline, amidephrine, and SK&F-89748 suppress food intake in rats. These compounds activate α 1 -adrenoceptors within the paraventricular hypothalamic nucleus (PVN) and may excite efferent fibers that inhibit feeding. Studies of the effects of α 1 -agonists suggest a specificity for feeding behavior, but no study to date has evaluated whether these agonists may suppress feeding behavior by the induction of malaise. Accordingly, the present experiment examined the ability of systemically administered cirazoline (0.1, 0.2, and 0.4 mg/kg, IP) to induce conditioned taste aversion (CTA) to a saccharin solution. Significant CTA was noted for 0.2 and 0.4 mg/kg cirazoline but not for 0.1 mg/kg cirazoline, compared to a vehicle treatment. The ED 50 for cirazoline-induced aversion was computed to be 0.3 mg/kg, which contrasts with an ED 50 value of 0.09 mg/kg for the effect of cirazoline on food intake (computed in other studies). More importantly, a 0.1 mg/kg dose of cirazoline, which is slightly greater than that of the ED 50 value for suppression of feeding, did not induce significant CTA in the present study. These results suggest that malaise is not a prominent factor in the suppressive activity of cirazoline on food intake and advocate the use of cirazoline as an effective appetite suppressant. |
| Databáze: | OpenAIRE |
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