Dermal application of nitric oxide in vivo: kinetics, biological responses, and therapeutic potential in humans
| Autor: | Norbert Pallua, Paul Fuchs, Ariane Römer, M. Mürtz, Adnana Paunel-Görgülü, Thomas Fritsch, A. Bozkurt, E E van Faassen, Gerrit Grieb, Christian Opländer, Christoph V. Suschek |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Bleeding Time Platelet Aggregation Administration Topical Chemistry Pharmaceutical Skin Absorption Vasodilator Agents Hemodynamics Vasodilation Pharmacology In Vitro Techniques Nitric Oxide Surgical Flaps Nitric oxide law.invention Ointments chemistry.chemical_compound In vivo law Blood plasma Humans Pharmacology (medical) Methemoglobin Skin Clinical pharmacology Microcirculation Electron Spin Resonance Spectroscopy Blood flow Middle Aged Bioavailability chemistry Regional Blood Flow Diffusion Chambers Culture Female |
| Zdroj: | Clinical pharmacology and therapeutics. 91(6) |
| ISSN: | 1532-6535 |
| Popis: | Many local hemodynamic and vascular disorders may be the result of impaired bioavailability of nitric oxide (NO). Previous findings point to a therapeutic potential of dermal NO application in the treatment of hemodynamic disorders, but no reliable data are available on the mechanisms, kinetics, or biological responses relating to cutaneous exposure to NO in humans in vivo. Here we show that, owing to its excellent diffusion capacity, cutaneously applied NO rapidly penetrates the epidermal barrier in significant amounts, strongly enriching skin tissue and blood plasma with its vasoactive derivates. In parallel, it significantly increased vasodilatation and blood flow and reduced thrombocyte aggregation capacity. Data presented here for the first time show that, in humans, dermal application of NO has strong potential for use in the therapy of local hemodynamic disorders arising from insufficient availability of NO or its bioactive derivates. Clinical Pharmacology & Therapeutics (2012); 91 6, 1074–1082. doi:10.1038/clpt.2011.366 |
| Databáze: | OpenAIRE |
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