Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet
| Autor: | Kazuto Shiga, Shiho Iwami, Shinnosuke Yasuda, Mayo Kamagata, Shigenobu Shibata, Hiroyuki Sasaki, Mizuho Hirao, Ai Todoh, Miku Tsubosaka, Teiji Ohtsu, Yuko Ikeda, Yuta Hattori, Konomi Tamura |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Circadian clock lcsh:Medicine Biology Glucagon Streptozocin General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Circadian Clocks Internal medicine medicine Animals Cysteine Circadian rhythm Insulin-Like Growth Factor I Mice Inbred ICR lcsh:R5-920 Podophyllin Suprachiasmatic nucleus Food resetting Insulin Protein digestive oral and skin physiology lcsh:R Glucagon secretion General Medicine Streptozotocin Diet Amino acid 030104 developmental biology Endocrinology Liver Commentary IGF-1 Dietary Proteins sense organs Entrainment (chronobiology) lcsh:Medicine (General) 030217 neurology & neurosurgery Signal Transduction medicine.drug |
| Zdroj: | EBioMedicine, Vol 28, Iss C, Pp 210-224 (2018) EBioMedicine |
| ISSN: | 2352-3964 |
| Popis: | The circadian system controls the behavior and multiple physiological functions. In mammals, the suprachiasmatic nucleus (SCN) acts as the master pacemaker and regulates the circadian clocks of peripheral tissues. The SCN receives information regarding the light-dark cycle and is thus synchronized to the external 24-hour environment. In contrast, peripheral clocks, such as the liver clock, receive information from the SCN and other factors; in particular, food intake which leads to insulin secretion induces strong entrainment of the liver clock. On the other hand, the liver clock of insulin-depleted mice treated with streptozotocin (STZ) has been shown to be entrained by scheduled feeding, suggesting that insulin is not necessary for entrainment of the liver clock by feeding. In this study, we aimed to elucidate additional mechanism on entraining liver clock by feeding a protein-only diet and/or amino-acid administration which does not increase insulin levels. We demonstrated that protein-only diet and cysteine administration elicit entrainment of the liver clock via glucagon secretion and/or insulin-like growth factors (IGF-1) production. Our findings suggest that glucagon and/or IGF-1 production are additional key factors in food-induced entrainment. |
| Databáze: | OpenAIRE |
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