Tolcapone in obsessive compulsive disorder: a randomized double-blind placebo-controlled crossover trial
| Autor: | Samuel R. Chamberlain, Roxanne Hook, Stephanie Valle, Eve Chesivoir, Jon E. Grant |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Obsessive-Compulsive Disorder medicine.medical_specialty tolcapone Placebo COMT inhibitor behavioral disciplines and activities Article Double blind chemistry.chemical_compound Double-Blind Method Obsessive compulsive obsessive compulsive disorder Internal medicine mental disorders Humans Medicine Pharmacology (medical) Cross-Over Studies treatment Tolcapone business.industry Dopaminergic Crossover study Psychiatry and Mental health chemistry pharmacology business Psychosocial medicine.drug |
| Zdroj: | International clinical psychopharmacology |
| Popis: | Despite the availability of evidence-based treatments for obsessive-compulsive disorder (OCD), not all patients experience sufficient benefit or are able to tolerate them. Tolcapone is a catechol-O-methyl-transferase (COMT) enzyme inhibitor that augments cortical dopaminergic transmission. Conduct a proof of concept study to examine whether a COMT inhibitor would reduce OCD symptoms to a greater extent than placebo. We conducted a randomized, placebo-controlled, double-blind crossover trial in adults with OCD (N = 20). Participants were assessed at baseline, after 2 weeks of tolcapone, and again after 2 weeks of placebo on measures of OCD symptom severity and psychosocial functioning. There was a 1-week washout period between the 2-week treatment phases. Two weeks of tolcapone was associated with significant improvement in OCD versus two weeks of placebo (t = 2.194, P = 0.0409). The mean percentage decreases in the total Yale-Brown obsessive-compulsive scale (YBOCS) scores for the entire sample over the corresponding 2-week period were 16.4% for tolcapone and 3.6% for placebo. These data indicate that brain penetrant COMT inhibitors merit further investigation as a candidate new treatment for OCD. |
| Databáze: | OpenAIRE |
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