Experience on the Treatment of Chronic Myelocytic Leukaemia (CML) in Blastic Crisis
| Autor: | Franco Mandelli, Giuliana Alimena, S. Nardelli, Luciana Annino, Sergio Amadori, Giuseppe Papa |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Vincristine medicine.medical_specialty Adolescent medicine.medical_treatment Remission Spontaneous Antineoplastic Agents Gastroenterology Chronic myelocytic leukaemia Prednisone hemic and lymphatic diseases Internal medicine medicine Humans Child Complete response Aged Chemotherapy business.industry Hematology Middle Aged Prognosis Leukemia Myeloid Acute Leukemia Myeloid Child Preschool Immunology Drug Evaluation Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1977.tb01506.x |
| Popis: | A group of 50 patients with chronic myelocytic leukaemia in blastic crisis were treated with different chemotherapeutic regimens. A total of 19 remissions (6 CR + 13 PR) were achieved with an overall and complete response rate of 38 % and 12 % respectively. Of the 4 patients presenting with a lymphoblast-like appearance of the blasts, the 3 treated with the combination of vincristine and prednisone all achieved remission (2 CR + 1 PR). Duration of survival was significantly longer in responding patients (median 11.5 versus 4.5 months). Either more effective therapeutic regimens or prevention by aggressively approaching the chronic phase are to be sought in order to improve the prognosis of blastic crisis of CML. |
| Databáze: | OpenAIRE |
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