Cognitive Event-Related Potentials in Young Adults With Cerebral Palsy: A Proof-of-Concept Study
| Autor: | Lackner, Christine L., Gorter, Jan Willem, Segalowitz, Sidney J., Hopmans, Sarah, Wilson, Julie, Viveiros, Helena, Secen, John, Stacey, Paul, Cassidy, Caitlin, Parvinchi, Diana, Roth, Sophia, Fehlings, Darcy, Ferro, Mark, Gonzalez, Andrea, Hall, Geoffrey, McCormick, Anna, Palisano, Robert, Rosenbaum, Peter |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population Audiology behavioral disciplines and activities 050105 experimental psychology Cerebral palsy 03 medical and health sciences 0302 clinical medicine Event-related potential medicine 0501 psychology and cognitive sciences Young adult education single-subject event-related potentials N100 education.field_of_study cerebral palsy 05 social sciences Cognition Gross Motor Function Classification System General Medicine clinical heterogeneity medicine.disease P200 Neurology Neurology (clinical) Psychology 030217 neurology & neurosurgery methodological feasibility |
| Zdroj: | Paediatrics Publications |
| ISSN: | 2169-5202 |
| Popis: | Cerebral palsy (CP) is a movement and posture disorder often accompanied by cognitive difficulties which can be assessed using event-related potentials (ERPs), an often-overlooked tool in this population. Here we describe our assessment protocol, examine its feasibility, and validate the use of single-subject ERP analyses in adolescents and young adults with CP, an analysis approach which recognizes the heterogeneity of the clinical population. This study involved a final sample of 9 adolescents/young adults with CP participating in the “MyStory” study (age range 16-29 years, Mage = 25.0 years; 6 female; Gross Motor Function Classification System level I [n = 4], II [n = 2], III [n = 1], IV [n = 1], and V [n = 1]). ERP components were elicited over medial prefrontal and central cortex (error- and correct-related negativities [ERN/CRN], error-positivity [Pe], N100, P200, N200, P300), as well as those generated over occipital cortex (P100, N170). Group and single-subject ERP statistics were computed for ERPs recorded over both areas. Using recently developed data analysis methods (independent components analysis and robust bootstrapped single-subject statistics), we measured the number of participants demonstrating significant condition differences at the timing of each ERP component of interest. We demonstrate good validity for ERPs recorded during 2 of our 3 tasks eliciting frontal activation (eg, 4 of 6 participants with usable data showed a significant single-subject medial frontal negativity condition difference in a context-switching task) and good validity for ERPs derived from a task engaging occipital regions (eg, 8 of 9 participants each showed a significant N170 face-object condition effect). |
| Databáze: | OpenAIRE |
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