Immunomodulatory effects of anaesthetic sevoflurane in septic mouse model
| Autor: | Lisha Mei, Dengke Liu, Ping Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine QH301-705.5 01 natural sciences Sevoflurane Immunomodulation Sepsis 03 medical and health sciences Immune system Coagulopathy Medicine Biology (General) Mortality Surrogate endpoint business.industry Mortality rate Surrgoate markers medicine.disease Pathophysiology Organ damage Puncture 030104 developmental biology Anesthesia Original Article General Agricultural and Biological Sciences business 010606 plant biology & botany medicine.drug |
| Zdroj: | Saudi Journal of Biological Sciences Saudi Journal of Biological Sciences, Vol 28, Iss 5, Pp 2733-2738 (2021) |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2021.03.023 |
| Popis: | Sepsis is one among the dangerous medical threat that is very much related to body’s immune system having no proper treatment for this condition. About19 million cases of sepsis have been recorded and out of which 5 million cases die every year. Sevoflurane other than controlling the depth of anaesthesia, it does have a vital role in immunomodulations. The study is focused on investigating the immunomodulatory effects of sevoflurane in the septic mouse model induced by CLP. Mortality rate, organ damage, inflammatory mediators, bacterial load, coagulopathy, hepto and renal functional changes, serum lactate, blood glucose, neutrophil sequestration and finally histopathological examination were investigated. The results were interesting that exposure to sevoflurane improves the polymicrobial abdominal sepsis outcome. Mice exposed to sevoflurane after CLP significantly improved outcomes of polymicrobial abdominal sepsis and reduced mortality by improving overall 7-day survival (83.3%) compared to mice without sevoflurane (no treatment group 16.6%) additionally decreasing the surrogate marker levels in the experimental sepsis animal model conducted. Our study suggests that the selection of certain anaesthetic drugs could be critical in the management of septic patients because their immunomodulatory effects could be large enough to affect sepsis pathophysiology. |
| Databáze: | OpenAIRE |
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