Tissue inhibitor of metalloproteinase 1, matrix metalloproteinase 9, αlpha-1 antitrypsin, metallothionein and urokinase type plasminogen activator receptor in skin biopsies from patients affected by autoimmune blistering diseases
| Autor: | Natalia Regina Mesa-Herrera, Jorge Enrique, Hong Yi, Juliana Calle-Isaza, Velásquez Velez, Georgia Dermatopathology, Paul B. Googe, Yulieth Alexandra Upegui, Isabel Cristina Avila, Ana Maria Abreu Velez, Michael S. Howard, Maria Mercedes Yepes Naranjo, Martha Luz Londoño |
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| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty alpha-1-antitrypsin Dermatitis herpetiformis lcsh:Dermatology Medicine skin and connective tissue diseases Pemphigus foliaceus Urokinase integumentary system business.industry Pemphigus vulgaris tissue inhibitor of metalloproteinases 1 lcsh:RL1-803 Tissue inhibitor of metalloproteinase endemic pemphigus foliaceus medicine.disease Urokinase receptor Pemphigus urokinase type plasminogen activator receptor Immunology matrix metalloproteinase 9 Bullous pemphigoid business autoimmune blistering skin diseases medicine.drug |
| Zdroj: | Nasza Dermatologia Online, Vol 4, Iss 3, Pp 275-280 (2013) |
| ISSN: | 2081-9390 |
| DOI: | 10.7241/ourd.20133.67 |
| Popis: | Introduction: Proteinases and proteinase inhibitors have been described to play a role in autoimmune skin blistering diseases. We studied skin lesional biopsies from patients affected by several autoimmune skin blistering diseases for proteinases and proteinase inhibitors. Methods: We utilized immunohistochemistry to evaluate biopsies for α-1-antitrypsin, human matrix metalloproteinase 9 (M MP9), human tissue inhibitor of metalloproteinases 1 (TIMP-1), metal lothionein and urokinase type plasminogen activator rece ptor (uPAR). We tested 30 patients affected by endemic pemphigus, 30 controls from the endemic area, and 15 normal controls. We also test ed 30 biopsies from patients with bullous pemphigoid (BP), 20 with pemphigus vulgaris (PV), 8 wit h pemphigus foliaceus, and 14 with dermatitis herpetiformis (DH). Results: Contrary to indings in the current literature, most autoimmune skin blistering disease biopsies were negative for uPAR and MMP9. Only some chronic patients with El Bagre-EPF were pos itive to MMP9 in the dermis, in proximity to telocytes. TIMP-1 and metallothionein were positive in half of the biopsies from BP patients at the basement membrane of the skin, within several skin appendices, in areas of dermal blood vessel inlammation and within dermal mesenchymal-epithe lial cell junctions. |
| Databáze: | OpenAIRE |
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