ATP-sensitive K+-channels in the human adult ventricular cardiomyocytes membrane
| Autor: | Yuri L. Shevchenko, Vladimir O. Samoilov, Andrew P. Babenko, Svetlana T. Kazantseva |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
medicine.medical_specialty Potassium Channels Adolescent Biophysics In Vitro Techniques Biochemistry Adenosine Triphosphate Structural Biology Internal medicine Genetics medicine Myocyte Humans Patch clamp Child Molecular Biology K channels Membrane potential Sarcolemma Chemistry Myocardium Human adult ventricular cardiomyocyte Myocardium metabolism Conductance Cell Biology ATP-sensitive K+-channel Endocrinology Membrane |
| Zdroj: | FEBS Letters. (2):148-150 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(92)81432-L |
| Popis: | Using the patch-clamp method in 27 different inside-out patches it was shown for the first time that they defined the basic parameters of the functioning of single ATP-sensitive K+ channels in the human adult ventricular cardiomyocytes membrane. At [K+]o = 140 mM single channel conductance (over the linear part of the I—V relation) reaches 100 pS. The possibility of the existence of these channels' conductance sublevels as well as the cluster character of their localization in sarcolemma is shown. The channel activity demonstrates an obvious run-down with τ at about a minute. The analysed channels possess one open and two closed states. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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