Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

Autor: J M C van Dijk, Hendriekje Eggink, Marina A. J. Tijssen, Dan Piña-Fuentes, J. C. van Zijl, Jan Willem J. Elting, D L M Oterdoom, Martijn Beudel, R. Brandsma, M. E. van Egmond, E Doldersum
Přispěvatelé: Neurology, Graduate School, CCA - Cancer Treatment and Quality of Life, ANS - Neuroinfection & -inflammation, AII - Inflammatory diseases, AGEM - Re-generation and cancer of the digestive system, AMS - Restoration & Development, Movement Disorder (MD)
Rok vydání: 2019
Předmět:
Male
Electroencephalography/methods
medicine.medical_treatment
EMG COHERENCE
Stimulation
0302 clinical medicine
PARKINSONS-DISEASE
CONNECTIVITY
Muscle
Skeletal/physiopathology
Deep brain stimulation
Dystonia
05 social sciences
Motor Cortex
Electroencephalography
Motor Cortex/physiopathology
Coherence (statistics)
Middle Aged
LOCAL-FIELD POTENTIALS
Sensory Systems
Clinical Practice
Neurology
Intermuscular coherence
SYNCHRONIZATION
Cardiology
Muscle
Biomarker (medicine)
Female
Skeletal/physiopathology
Electromyography/methods
Dystonia/diagnosis
Adult
medicine.medical_specialty
Globus Pallidus
INTERNAL GLOBUS-PALLIDUS
050105 experimental psychology
MOVEMENT
03 medical and health sciences
Beta band
Deep Brain Stimulation/methods
Physiology (medical)
Internal medicine
OSCILLATIONS
medicine
Humans
Globus Pallidus/physiopathology
0501 psychology and cognitive sciences
Muscle
Skeletal
Electromyography
business.industry
Biomarker
medicine.disease
Confidence interval
nervous system diseases
nervous system
MUSCLE-ACTIVITY
PATTERNS
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Clinical neurophysiology, 130(8), 1351-1357. Elsevier Ireland Ltd
Clinical Neurophysiology, 130(8), 1351-1357. ELSEVIER IRELAND LTD
ISSN: 1388-2457
DOI: 10.1016/j.clinph.2019.04.717
Popis: Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights
Databáze: OpenAIRE
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