Sirt3-Sod2-mROS-Mediated Manganese Triggered Hepatic Mitochondrial Dysfunction and Lipotoxicity in a Freshwater Teleost

Autor:	Tao Zhao, Wu-Hong Lv, Christer Hogstrand, Dian-Guang Zhang, Yi-Chuang Xu, Yi-Huan Xu, Zhi Luo
Rok vydání:	2022
Předmět:	PPAR gamma Manganese Oxidative Stress Superoxide Dismutase Sirtuin 3 Animals Humans Environmental Chemistry Fresh Water General Chemistry Reactive Oxygen Species Antioxidants Mitochondria
Zdroj:	Environmental Science & Technology. 56:8020-8033
ISSN:	1520-5851 0013-936X
DOI:	10.1021/acs.est.2c00585
Popis:	Exposure to excessive manganese (Mn) is toxic to humans and animals. However, the toxic effects and mechanisms of excessive Mn influencing the vertebrates have been highly overlooked. In the present study, dietary Mn overload significantly increased hepatic lipid and Mn contents, decreased superoxide dismutase 2 (Sod2) activity, increased the Sod2 acetylation level, and induced mitochondrial dysfunction; Mn induced mitochondrial dysfunction through Mtf1/sirtuin 3 (Sirt3)-mediated acetylation of Sod2 at the sites K55 and K70. Meanwhile, mitochondrial oxidative stress was involved in Mn-induced lipotoxicity. Mechanistically, Mn-induced lipotoxicity was via oxidative stress-induced Hsf1 nucleus translocation and its DNA binding capacity to the regions of a
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd9aa2e6bb36c9a21eea9ca43da06bd https://doi.org/10.1021/acs.est.2c00585 Zobrazit plný text záznamu