MMPs, TIMPs and BMP-4 in medial rectus muscle obtained from intermittent exotropia patients and their clinical correlations
| Autor: | Dong Gyu Choi, Yoon Pyo Lee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Visual Acuity Enzyme-Linked Immunosorbent Assay Bone Morphogenetic Protein 4 Ophthalmologic Surgical Procedures Matrix metalloproteinase Positive correlation 03 medical and health sciences Young Adult 0302 clinical medicine Ophthalmology Medicine Humans Child Rank correlation Retrospective Studies Tissue Inhibitor of Metalloproteinase-2 business.industry Medial rectus muscle General Medicine Tissue inhibitor of metalloproteinase Middle Aged Prognosis Matrix Metalloproteinases Oculomotor Muscles Child Preschool 030221 ophthalmology & optometry Exotropia Minimum deviation Female Negative correlation business Intermittent exotropia 030217 neurology & neurosurgery Biomarkers Follow-Up Studies |
| Zdroj: | Acta ophthalmologicaReferences. 98(1) |
| ISSN: | 1755-3768 |
| Popis: | Background To measure the amounts of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2 and bone morphogenetic protein (BMP)-4 in medial rectus muscle (MR) tissue obtained from intermittent exotropia (IXT) patients and to investigate the correlation between each protein amount and the clinical features of IXT including angles of deviation, age at surgery, duration of IXT and postoperative recurrence. Methods The protein amounts were measured by enzyme-linked immunosorbent assay (ELISA) in MR collected during surgery for 78 IXT patients. Results The mean amount of MMP-2 per mm of resected MR was 0.86 ng, of MMP-9, 2.72 ng, of TIMP-1, 1.99 ng, of TIMP-2, 0.92 ng and of BMP-4, 0.82 pg. MMP-2 showed a positive correlation with angle of deviation at distance and at near, age at surgery and duration of IXT (p = 0.000, p = 0.000, p = 0.000, p = 0.022, respectively, Spearman's rank correlation analysis). MMP-9 showed a positive correlation with angle of deviation at distance and at near (p = 0.001, p = 0.024) and BMP-4 showed a positive correlation with angle of deviation at distance (p = 0.012). TIMP-1 showed a negative correlation with angle of deviation at distance and at near (p = 0.003, p = 0.000). Conclusion In IXT patients, MMPs and BMP-4 tended to increase and TIMPs to decrease with increasing angle of deviation, greater age at surgery and longer duration of IXT. |
| Databáze: | OpenAIRE |
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