Excess fat in the abdomen but not general obesity is associated with poorer metabolic and cardiovascular health in premenopausal and postmenopausal Asian women

Autor: Victor H.H. Goh, William G. Hart
Rok vydání: 2017
Předmět:
Adult
Blood Glucose
medicine.medical_specialty
Hormone Replacement Therapy
medicine.medical_treatment
Abdominal Fat
Physiology
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Asian People
Diabetes mellitus
Internal medicine
medicine
Diabetes Mellitus
Humans
Insulin
Obesity
Abdominal obesity
Metabolic Syndrome
Singapore
Estradiol
business.industry
Obstetrics and Gynecology
Hormone replacement therapy (menopause)
Middle Aged
medicine.disease
Menopause
Postmenopause
Endocrinology
medicine.anatomical_structure
Cross-Sectional Studies
Premenopause
Cardiovascular Diseases
Abdomen
Female
Metabolic syndrome
medicine.symptom
Insulin Resistance
business
Zdroj: Maturitas. 107
ISSN: 1873-4111
Popis: Objectives To examine the associations of various metabolites and hormones and hormone replacement therapy (HRT) with obesity. Methods This is a cross-sectional study of 1326 Singaporean women. A DXA-derived percent body fat (PBF) of ≥35% and percent abdominal fat (PAbdF) of >21.8% were used, respectively, to define women with general (GOb) and abdominal (AbdOb) obesity. Results Higher levels of insulin and glucose, lower levels of HDL, higher levels of TC/HDL and HOMA values, and different levels of some hormones were noted only in the women with abdominal, and not general obesity. The incidence of general and abdominal obesity was higher in postmenopausal women with or without HRT, except that those who were on conjugated estradiol-only HRT had no increase in the incidence of general obesity compared with premenopausal women. Conclusions Abdominal obesity is associated with insulin resistance and with higher risks of metabolic syndrome and cardiovascular diseases, whereas general obesity is not. Abdominal obesity may predispose to a higher risk of diabetes. The onset of the menopause tends to increase the incidence of general and abdominal obesity, except that postmenopausal women on conjugated estradiol HRT appear to be relatively protected from general obesity.
Databáze: OpenAIRE
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