A fucoidan fraction from Ascophyllum nodosum
| Autor: | Marie-France Marais, Jean-Paul Joseleau |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Magnetic Resonance Spectroscopy
Antineoplastic Agents Fraction (chemistry) Phaeophyta Polysaccharide Methylation Biochemistry Analytical Chemistry chemistry.chemical_compound Sulfation Polysaccharides Spectroscopy Fourier Transform Infrared Side chain Sulfate Fucose chemistry.chemical_classification biology Sulfates Fucoidan Organic Chemistry General Medicine Nuclear magnetic resonance spectroscopy biology.organism_classification chemistry Ascophyllum |
| Zdroj: | Carbohydrate Research. 336:155-159 |
| ISSN: | 0008-6215 |
| DOI: | 10.1016/s0008-6215(01)00257-9 |
| Popis: | A fucoidan fraction was purified from the brown alga Ascophyllum nodosum. The polysaccharide contained L-fucose and sulfate as the only constituents. Combination of methylation analysis, Smith degradation, FTIR and NMR spectroscopy on the native and the de-sulfated polymers demonstrated that the fucoidan consisted of a highly branched core region with primarily alpha-(1--3)-linked fucosyl residues and a few alpha-(1--4) linkages. Branch points were at position 2 of the --3-linked internal residues. The side chains consisted of single and multi-unit fucosyl residues. The combined analytical data suggested also a complex sulfation pattern with substitution principally at position 2 and/or position 4. Such diversity in the structural features of this fucoidan may be of importance for its various biological properties. |
| Databáze: | OpenAIRE |
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