Immune context characterization and heterogeneity in primary tumors and pulmonary metastases from renal cell carcinoma
Autor: | Luca Ampollini, Umberto Maestroni, Michele Rusca, Alessio Cortellini, Francesco Paolo Pilato, Giuseppe Caruso, Nicoletta Campanini, Melissa Bersanelli, Sebastiano Buti, Elena Varotti, Clara Indira Dadomo, Elena Rapacchi, Paolo Carbognani, Enrico Maria Silini, Francesco Leonardi, Francesco Ziglioli, Letizia Gnetti |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Male Pathology medicine.medical_specialty Lung Neoplasms Lymphocyte medicine.medical_treatment Immunology Programmed Cell Death 1 Receptor Context (language use) CD8-Positive T-Lymphocytes urologic and male genital diseases B7-H1 Antigen 03 medical and health sciences 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating Renal cell carcinoma PD-L1 medicine Immunology and Allergy Humans Neoplasm Metastasis Carcinoma Renal Cell Aged Neoplasm Staging Retrospective Studies biology business.industry Immunotherapy Middle Aged medicine.disease Survival Analysis Nephrectomy Kidney Neoplasms 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis biology.protein Female Metastasectomy business Follow-Up Studies |
Zdroj: | Immunotherapy. 11(1) |
ISSN: | 1750-7448 |
Popis: | Aim: The knowledge of the immune context of renal cell carcinoma (RCC) is useful to predict benefit from immunotherapy. We retrospectively characterized the immune context of RCC patients underwent primary nephrectomy and pulmonary metastasectomy. Materials & methods: Intratumoral infiltrating lymphocytes and peritumoral renal infiltrating lymphocytes, lymphocyte subpopulations (CD4+, CD8+), PD-1, PD-L1 were explored in paired samples of primary RCC (T) and respective pulmonary metastases (M). Results: The immune variables demonstrated intralesional and intratumoral heterogeneity. Intralesional lymphocyte heterogeneity reached 76% of cases in T, 28% in M. The heterogeneity rate for PD-L1 expression was from 44% (T) to 56% (M); it correlated with better survival. Conclusion: The immune context of RCC is highly variable both within a given tumor and among primary and metastases. |
Databáze: | OpenAIRE |
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