Immune context characterization and heterogeneity in primary tumors and pulmonary metastases from renal cell carcinoma

Autor: Luca Ampollini, Umberto Maestroni, Michele Rusca, Alessio Cortellini, Francesco Paolo Pilato, Giuseppe Caruso, Nicoletta Campanini, Melissa Bersanelli, Sebastiano Buti, Elena Varotti, Clara Indira Dadomo, Elena Rapacchi, Paolo Carbognani, Enrico Maria Silini, Francesco Leonardi, Francesco Ziglioli, Letizia Gnetti
Rok vydání: 2019
Předmět:
0301 basic medicine
CD4-Positive T-Lymphocytes
Male
Pathology
medicine.medical_specialty
Lung Neoplasms
Lymphocyte
medicine.medical_treatment
Immunology
Programmed Cell Death 1 Receptor
Context (language use)
CD8-Positive T-Lymphocytes
urologic and male genital diseases
B7-H1 Antigen
03 medical and health sciences
0302 clinical medicine
Immune system
Lymphocytes
Tumor-Infiltrating
Renal cell carcinoma
PD-L1
medicine
Immunology and Allergy
Humans
Neoplasm Metastasis
Carcinoma
Renal Cell
Aged
Neoplasm Staging
Retrospective Studies
biology
business.industry
Immunotherapy
Middle Aged
medicine.disease
Survival Analysis
Nephrectomy
Kidney Neoplasms
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
biology.protein
Female
Metastasectomy
business
Follow-Up Studies
Zdroj: Immunotherapy. 11(1)
ISSN: 1750-7448
Popis: Aim: The knowledge of the immune context of renal cell carcinoma (RCC) is useful to predict benefit from immunotherapy. We retrospectively characterized the immune context of RCC patients underwent primary nephrectomy and pulmonary metastasectomy. Materials & methods: Intratumoral infiltrating lymphocytes and peritumoral renal infiltrating lymphocytes, lymphocyte subpopulations (CD4+, CD8+), PD-1, PD-L1 were explored in paired samples of primary RCC (T) and respective pulmonary metastases (M). Results: The immune variables demonstrated intralesional and intratumoral heterogeneity. Intralesional lymphocyte heterogeneity reached 76% of cases in T, 28% in M. The heterogeneity rate for PD-L1 expression was from 44% (T) to 56% (M); it correlated with better survival. Conclusion: The immune context of RCC is highly variable both within a given tumor and among primary and metastases.
Databáze: OpenAIRE
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