Thalidomide-dexamethasone plus pegylated liposomal doxorubicin vs. thalidomide-dexamethasone: a case-matched study in advanced multiple myeloma
| Autor: | Pietro Leoni, Laura Corvatta, Antonio Palumbo, Massimo Offidani, Maria-Novella Piersantelli, Sara Bringhen, Patrizia Falco, Monica Marconi, Ilaria Avonto, Mario Boccadoro, Claudia Polloni |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Salvage therapy Gastroenterology Dexamethasone Disease-Free Survival Polyethylene Glycols Refractory Recurrence Internal medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans Survival rate Multiple myeloma Aged Retrospective Studies Aged 80 and over Salvage Therapy Dose-Response Relationship Drug business.industry Hematology General Medicine Middle Aged medicine.disease Surgery Thalidomide Survival Rate Regimen Treatment Outcome Doxorubicin Case-Control Studies Toxicity Liposomes Disease Progression Female business Multiple Myeloma medicine.drug Follow-Up Studies |
| Zdroj: | European journal of haematology. 78(4) |
| ISSN: | 0902-4441 |
| Popis: | Objectives: Nearly all patients with multiple myeloma (MM) relapse or become refractory to front-line therapy. Several salvage therapies have been explored, but the optimal combination regimen has not been defined. We performed a case-matched study comparing patients with relapsed/refractory MM receiving thalidomide–dexamethasone alone or the combination thalidomide–dexamethasone–liposomal pegylated doxorubicin. Methods: Forty-seven patients received thalidomide (100 mg/d), dexamethasone (40 mg p.o. on days 1–4 and 9–12), and pegylated liposomal doxorubicin (40 mg/m2 on day 1 every 28 d) (ThaDD). Their clinical outcome was compared with that of 47 pair mates selected from patients treated at relapse with thalidomide (100 mg/d) and dexamethasone (40 mg p.o. on days 1–4) (Thal–Dex) and matched for age, β2-microglobulin and previous therapy. Results and conclusions: Overall response rate was significantly higher in ThaDD group (92% vs. 63.5%; P |
| Databáze: | OpenAIRE |
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