Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation

Autor: Adriana Rochetto Assalin, Flávio Henrique Ferreira Galvão, Lucas Souto Nacif, Agustin Moscoso Vintimilla, Joel Avancini Rocha-Filho, Luciana Bertocco de Paiva Haddad, Cinthia Lanchotte, Yumi Ricucci Shinkado, Luiz Augusto Carneiro D'Albuquerque, Estela Regina Ramos Figueira
Rok vydání: 2021
Předmět:
Zdroj: BMC Gastroenterology, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Gastroenterology
ISSN: 1471-230X
DOI: 10.1186/s12876-021-01830-5
Popis: Background The aim of this study was to analyze prognostic indicators of in-hospital mortality among patients listed for urgent liver transplantation (LT) for non-acetaminophen (APAP)-induced acute liver failure (ALF). Methods ALF patients listed for LT according to the King’s College Criteria were retrospectively reviewed. Variables were recorded from medical records and electronic databases (HCMED and RedCap). Results The study included 100 patients, of which 69 were subject to LT and 31 died while waiting for LT. Patients were 35.5 ± 14.73 years old, and 78% were females. The main etiologies were virus (17%), drug-induced (32%), autoimmune (15%), and indeterminate hepatitis (31%). The prioritization-to-LT time interval was 1.5 days (0–9). The non-LT patients showed higher lactate (8.71 ± 5.36 vs. 4.48 ± 3.33 mmol/L), creatinine (229 ± 207 vs. 137 ± 136 µm/L), MELD (44 ± 8 vs. 38 ± 8), and BiLE scores (15.8 ± 5.5 vs. 10.3 ± 4.1) compared to LT patients (p Conclusions CL and BiLE scores predict mortality with more accuracy than MELD in patients with ALF during prioritization time. Creatinine and lactate are independent prognostic factors for mortality.
Databáze: OpenAIRE
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