HIV-1 RNA processing as therapeutic target: characterization of small molecule modulators of HIV-1 RNA processing and transport

Autor:	Raymond Wong, Alan Cochrane, Peter Stoilov, Matthew Haaland, Ahalya Balachandran
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	biology Chemistry virus diseases Bioinformatics Small molecule Genome Hiv 1 rna Cell biology Infectious Diseases Protein structure Cytoplasm Virology RNA splicing Gene expression biology.protein Oral Presentation Antibody
Zdroj:	Retrovirology
ISSN:	1742-4690
Popis:	Background Control of RNA processing plays a central role in the expression of the HIV-1 genome. From a single 9kb transcript, more than 40 mRNAs are generated through suboptimal splicing, a subset of which are dependent upon the HIV-1 factor Rev for export to the cytoplasm. To identify small molecule modulators of HIV-1 RNA processing, we performed a screen to isolate compounds capable of inhibiting HIV-1 gene expression postintegration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd59694d20ece4eb13744aa17d57680 http://europepmc.org/articles/PMC3848095 Zobrazit plný text záznamu Plný text ve formátu PDF