Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review
| Autor: | Ana L. Candido, Fernando M. Reis, Laura M. L. Carvalho, Cláudia N. Ferreira, Fernanda F. C. Nunes, Karina Braga Gomes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
endocrine system diseases
Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Inflammation Bioinformatics Diseases of the endocrine glands. Clinical endocrinology Pathogenesis hyperandrogenism Mice 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance medicine Animals Humans Obesity pathophysiology Metabolic Syndrome 030219 obstetrics & reproductive medicine business.industry Hyperandrogenism Type 2 Diabetes Mellitus nutritional and metabolic diseases medicine.disease RC648-665 Polycystic ovary female genital diseases and pregnancy complications Diabetes Mellitus Type 2 polycystic ovary syndrome inflammation hemostasis Female Insulin Resistance Metabolic syndrome medicine.symptom business metabolism Dyslipidemia Signal Transduction |
| Zdroj: | Endocrine Regulations, Vol 52, Iss 4, Pp 208-221 (2018) |
| ISSN: | 1336-0329 |
| Popis: | Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, amenorrhea, and polycystic ovaries. This endocrinopathy is associated with many metabolic disorders such as dyslipidemia and insulin resistance, with increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular complications. Inflammation is likely to play an important role in the promoting these metabolic imbalances, while prothrombotic and pro-oxidative mechanisms further contribute to the cardiovascular risk of these patients. The etiology of PCOS is still not fully understood, but there is evidence of genetic and environmental components. This review aims to discuss some molecular pathways associated with PCOS that could contribute to the better understanding about this syndrome. Recent evidence suggests that intrauterine exposure of female mice to an excess of anti-Müllerian hormone may induce PCOS features in their post-natal life. High cytokine levels and cytokine gene polymorphisms also appear to be associated with the pathophysiology of PCOS. Furthermore, high levels of microparticles may contribute to the altered hemostasis and enhanced inflammation in PCOS. All these mechanisms may be relevant to clarify some aspects of PCOS pathogenesis and inspire new strategies to prevent the syndrome as well as treat its symptoms and mitigate the risk of long-term complications. |
| Databáze: | OpenAIRE |
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