Circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis: a new association

Autor:	Yuben P, Moodley
Rok vydání:	2021
Předmět:	Pulmonary and Respiratory Medicine Vital Capacity Disease Progression Humans DNA respiratory system Brief Communication idiopathic pulmonary fibrosis respiratory tract diseases
Zdroj:	Thorax
ISSN:	1468-3296 0040-6376
Popis:	Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with unclear aetiology and poorly understood pathophysiology. Although plasma levels of circulating cell-free DNA (ccf-DNA) and metabolomic changes have been reported in IPF, the associations between ccf-DNA levels and metabolic derangements in lung fibrosis are unclear. Here, we demonstrate that ccf-double-stranded DNA (dsDNA) is increased in patients with IPF with rapid progression of disease compared with slow progressors and healthy controls and that ccf-dsDNA associates with amino acid metabolism, energy metabolism and lipid metabolism pathways in patients with IPF.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd1c9818efb8607d812c8da468f5a91 https://doi.org/10.1136/thoraxjnl-2021-218192 Zobrazit plný text záznamu