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Yu Song,1 Mi Zhou,2 Qingmei Gong,1 Jinlin Guo3 1Department of Intensive Care Unit, Shanxi Provincial Peopleâs Hospital, Taiyuan, Shanxi, 030012, Peopleâs Republic of China; 2Department of Pharmacy, Childrenâs Hospital of Soochow University, Suzhou, Jiangsu, 215000, Peopleâs Republic of China; 3Department of Pharmacy, Shanxi Provincial Peopleâs Hospital, Taiyuan, Shanxi, 030012, Peopleâs Republic of ChinaCorrespondence: Qingmei Gong, Intensive Care Unit, Shanxi Provincial Peopleâs Hospital, Shuangtasi Street 59#, Taiyuan, Shanxi, 030012, Peopleâs Republic of China, Tel +86-13934647196, Email ty_gqm@163.com Jinlin Guo, Department of Pharmacy, Shanxi Provincial Peopleâs Hospital, Shuangtasi Street 59#, Taiyuan, Shanxi, 030012, Peopleâs Republic of China, Tel +86-18335136581, Email taiggll@foxmail.comAbstract: This is the first report describing co-infection of Scedosporium apiospermum and Lichtheimia corymbifera caused by biogas inhalation in two people without underlying medical conditions. Two patients fell into the same pig manure pit at the same time while rescuing another patient (this person died in a few hours) and inhaled biogas. Both patients were diagnosed with pulmonary fungal disease and developed acute liver failure around Day 52. Their results were negative for the 1,3-β-d-glucan test and weakly positive for the galactomannan test. They were treated with amphotericin B and/or posaconazole without surgery. The patient in case 2 required amphotericin B deoxycholate aerosol inhalation to complete the treatment. Both patients recovered completely. For patients with mucormycosis confined to the lungs who cannot tolerate intravenous drip amphotericin B, increasing the dose of nebulised administration maybe a salvage regimen.Keywords: Scedosporium apiospermum, pulmonary mucormycosis, acute liver failure, Lichtheimia corymbifera, immunocompetent patients, inhalation of biogas |
