A comprehensive one-year correlation analysis between prevalence and number of sars-cov-2 rna copies detected in wastewater from 8 sicilian cities in italy

Autor: Maida, Carmelo, Priano, Walter, Palermo, Roberta, Purpari, Giuseppa, Russo, Arianna, Giangreco, Viviana, Andolina, Gina, Graziano, Giorgio, Vitale, Francesco, Guercio, Annalisa, Gucciardi, Francesca, Tramuto, Fabio, Mazzucco, Walter
Přispěvatelé: Maida, Carmelo, Priano, Walter, Palermo, Roberta, Purpari, Giuseppa, Russo, Arianna, Giangreco, Viviana, Andolina, Gina, Graziano, Giorgio, Vitale, Francesco, Guercio, Annalisa, Gucciardi, Francesca, Tramuto, Fabio, Mazzucco, Walter
Rok vydání: 2023
Předmět:
Zdroj: Population Medicine. 5
ISSN: 2654-1459
DOI: 10.18332/popmed/164465
Popis: Background and objectives: Several authors have reported positive correlations between wastewater SARS-CoV-2 concentrations and the community’s burden of infection, providing information about the disease’s epidemiological trend. This pre-post study evaluated – within a year of active surveillance, from October 1st,2021, to September 30th, 2022 – the relation between daily SARSCoV-2 prevalence and the number of genome copies/L detected in West Sicily wastewater samples. This study is part of a national framework coordinated by Istituto Superiore di Sanità. Methods: Quantitative data from analysing 486 wastewater samples collected from 9 purification plants in 8 Sicilian cities (Agrigento, Bagheria, Caltanissetta, Enna, Marsala, Mazara del Vallo, Palermo, and Trapani) were obtained. Correlation and logistic regression analysis were performed between the communal-based aggregated prevalence of daily SARS-CoV-2 cases obtained from the integrated national surveillance system and the number of genomic copies/L derived from wastewater analysis for different times (day-prevalence t0, t7, t14) and different periods (0- to 6-, 6- to 12- and comprehensive 12 months). Results: A moderate-high correlation index was retrieved for 0- to 6- months (October 2021–March 2022, t0: r=0.75, R2=0.57; t7 r=0.76, R2=0.58, t14 r=0.76, R2=0.58) and overall analyses (October 2021–October 2022, t0 r=0.63, R2=0.40; t7 r=0.62, R2=0.38; t14 r=0.59, R2=0.35). On the other hand, 6- to 12- months analysis displayed a relevant decline in correlation (March 2022–October 2022, t0 r=0.19, R2=0.04; t7 r=0.17, R2=0.03, p=0.004; t14 r=0.11, R2=0.01). All data except t14 were statistically significant (p
Databáze: OpenAIRE