Updated clinical overview on cardiac laminopathies: an electrical and mechanical disease
| Autor: | Sara Benedetti, Maurizio Ferrari, Simone Sala, Lorenzo Gigli, Giovanni Peretto, C. Di Resta, P. Della Bella |
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| Přispěvatelé: | Peretto, G., Sala, S., Benedetti, S., Di Resta, C., Gigli, L., Ferrari, M., Della Bella, P. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Heart disease Heart Diseases Cardiomyopathy LMNA heart failure Disease 030204 cardiovascular system & hematology arrhythmia Asymptomatic sudden cardiac death Sudden cardiac death 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans lamin genetics 030212 general & internal medicine Musculoskeletal Diseases Special Issue on Laminopathies business.industry Dilated cardiomyopathy Cell Biology medicine.disease Lamin Type A Heart failure Cardiology genetic medicine.symptom business arrhythmias cardiomyopathy |
| Zdroj: | Nucleus |
| ISSN: | 1949-1042 1949-1034 |
| Popis: | Cardiac laminopathies, associated with mutations in the LMNA gene, encompass a wide spectrum of clinical manifestations, involving electrical and mechanical alterations of cardiomyocytes. Thus, dilated cardiomyopathy, bradyarrhythmias and atrial or ventricular tachyarrhythmias may occur in a number of combined phenotypes. Nowadays, some attempt has been made to identify clinical predictors for the most life-threatening complications of LMNA-associated heart disease, i.e. sudden cardiac death and end-stage heart failure. The goal of this manuscript is to combine the most recent evidences in an updated review to show the state-of-the-art of such a complex disease group. This is supposed to be the starting point to collect more data and design new ad hoc studies to identify clinically useful predictors to stratify risk in mutation carriers, including probands and their asymptomatic relatives. |
| Databáze: | OpenAIRE |
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