Analgesic effects of botulinum toxin A: a randomized, placebo-controlled clinical trial
| Autor: | H. K. Graham, K Brereton, C Baillieu, Roslyn N. Boyd, J Low, G. S. Nattrass, S Barwood |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Analgesic Placebo Cerebral palsy law.invention Spastic cerebral palsy Double-Blind Method Developmental Neuroscience Randomized controlled trial law medicine Spastic Hip Dislocation Humans Botulinum Toxins Type A Child Muscle Skeletal Pain Postoperative business.industry Cerebral Palsy medicine.disease Surgery Treatment Outcome Neuromuscular Agents Child Preschool Anesthesia Pediatrics Perinatology and Child Health Female Neurology (clinical) medicine.symptom Intramuscular injection business muscle spasm Muscle Contraction |
| Zdroj: | Developmental Medicine & Child Neurology. 42:116-121 |
| ISSN: | 0012-1622 |
| Popis: | Postoperative pain in children with spastic cerebral palsy (CP) is often attributed to muscle spasm and is difficult to manage using opiates and benzodiazepines. Adductor-release surgery to treat or prevent hip dislocation in children with spastic CP is frequently performed and is often accompanied by severe postoperative pain and spasm. A double-blinded, randomized, placebo-controlled clinical trial of 16 patients (mean age 4.7 years) with a mainly spastic type of CP (either diplegic or quadriplegic in distribution) was used to test the hypothesis that a significant proportion of postoperative pain is secondary to muscle spasm and, therefore, might be reduced by a preoperative chemodenervation of the target surgical muscle by intramuscular injection of botulinum toxin A (BTX/A). Compared with the placebo, BTX/A was found to be associated with a reduction in mean pain scores of 74% (P |
| Databáze: | OpenAIRE |
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