Effects of an oral superoxide dismutase enzyme supplementation on indices of oxidative stress, proviral load, and CD4:CD8 ratios in asymptomatic FIV-infected cats

Autor: Craig B. Webb, Tracy L. Lehman, Kelly McCord
Rok vydání: 2008
Předmět:
Male
Feline immunodeficiency virus
medicine.medical_specialty
Antioxidant
Erythrocytes
Neutrophils
animal diseases
viruses
medicine.medical_treatment
T-Lymphocytes
CD4-CD8 Ratio
Administration
Oral
Biological Availability
Immunodeficiency Virus
Feline
medicine.disease_cause
Asymptomatic
Antioxidants
Superoxide dismutase
chemistry.chemical_compound
Random Allocation
Internal medicine
Diabetes mellitus
Feline Acquired Immunodeficiency Syndrome
Malondialdehyde
medicine
Animals
Small Animals
Glutathione Peroxidase
CATS
biology
Superoxide Dismutase
virus diseases
Glutathione
Viral Load
biology.organism_classification
medicine.disease
Oxidative Stress
Endocrinology
Treatment Outcome
chemistry
Immunology
Acute Disease
Dietary Supplements
biology.protein
Cats
Female
medicine.symptom
Oxidative stress
Zdroj: Journal of feline medicine and surgery. 10(5)
ISSN: 1098-612X
Popis: This study was designed to test the effect of antioxidant supplementation on feline immunodeficiency virus (FIV)-infected felines. Six acutely FIV-infected cats (≥16 weeks post-inoculation) were given a propriety oral superoxide dismutase (SOD) supplement (Oxstrin; Nutramax Laboratories) for 30 days. Following supplementation, the erythrocyte SOD enzyme concentration was significantly greater in the supplemented FIV-infected group than the uninfected control group or the unsupplemented FIV-infected group. The CD4+ to CD8+ ratio increased significantly (0.66–0.88) in the SOD supplemented FIV-infected cats but not in the unsupplemented FIV-infected cats. Proviral load and reduced glutathione (GSH) levels in leukocyte cell types did not change significantly following supplementation. Antioxidant supplementation resulted in an increase in SOD levels, confirming the oral bioavailability of the compound in FIV-infected cats. This result warrants further investigation with trials of antioxidant therapy in FIV-infected cats that are showing clinical manifestations of their disease, as well as in other feline patients where oxidative stress likely contributes to disease pathogenesis, such as diabetes mellitus and chronic renal failure.
Databáze: OpenAIRE
Externí odkaz: