Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia

Autor: Liya Yang, Sarah Forbes-Robertson, K. Klampfl, Sabine Müller, J. Catharina Duvigneau, Claudia Mehler-Wex, Manfred Gerlach, Johannes Thome, Regina Taurines, Jasmin Romanos
Přispěvatelé: Department of Child and Adolescent Psychiatry and Psychotherapy, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Institute of Life Science, University of Wales, Department of Biomedical Sciences, University of Veterinary Medicine [Vienna] (Vetmeduni), Universität Ulm - Ulm University [Ulm, Allemagne]
Rok vydání: 2009
Předmět:
Male
Biological marker
Mitochondrial complex I
75-kDa subunit
Early onset schizophrenia
Autistic spectrum disorder
Gene Expression
medicine.disease_cause
0302 clinical medicine
ddc:150
Gene expression
Developmental and Educational Psychology
Psychology
Child
0303 health sciences
Reverse Transcriptase Polymerase Chain Reaction
Psychological Disorders
Mental Health Treatment and Prevention
General Medicine
Psychiatry and Mental health
psychische Störungen
Behandlung und Prävention
Schizophrenia
Autism spectrum disorder
Biomarker (medicine)
Female
Clinical psychology
medicine.medical_specialty
Adolescent
Protein subunit
behavioral disciplines and activities
03 medical and health sciences
Internal medicine
mental disorders
medicine
Humans
RNA
Messenger
Gene
030304 developmental biology
Psychiatric Status Rating Scales
Electron Transport Complex I
Case-control study
medicine.disease
Endocrinology
Psychologie
Child Development Disorders
Pervasive
Case-Control Studies
Pediatrics
Perinatology and Child Health
Biomarkers
030217 neurology & neurosurgery
Oxidative stress
Zdroj: European Child and Adolescent Psychiatry
European Child and Adolescent Psychiatry, Springer Verlag (Germany), 2009, 19 (5), pp.441-448. ⟨10.1007/s00787-009-0074-z⟩
European Child & Adolescent Psychiatry
ISSN: 1435-165X
1018-8827
Popis: International audience; Searching for a peripheral biological marker for schizophrenia, we previously reported on elevated mitochondrial complex I 75-kDa subunit mRNA-blood concentrations in early onset schizophrenia (EOS). The aim of this study was to further evaluate the utility of this gene as a potential marker for schizophrenia. Both--schizophrenia and autism--are suggested to be neuronal maldevelopmental disorders with reports of mitochondrial dysfunction and increased oxidative stress. Therefore we have investigated the expression levels of mitochondrial complex I 75-kDa subunit mRNA in whole blood of children with autistic spectrum disorder (ASD) and a group of adolescent acute first-episode EOS patients in comparison to matched controls. We have found that compared to the respective controls only the group of EOS patients--and not the ASD group--showed a significantly altered expression of the complex I 75-kDa subunit mRNA. Although further studies are necessary to test for the specificity of this marker, our findings point to the potential use of the mitochondrial complex I as a biomarker for schizophrenia.
Databáze: OpenAIRE
Externí odkaz: