Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia
Autor: | Liya Yang, Sarah Forbes-Robertson, K. Klampfl, Sabine Müller, J. Catharina Duvigneau, Claudia Mehler-Wex, Manfred Gerlach, Johannes Thome, Regina Taurines, Jasmin Romanos |
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Přispěvatelé: | Department of Child and Adolescent Psychiatry and Psychotherapy, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Institute of Life Science, University of Wales, Department of Biomedical Sciences, University of Veterinary Medicine [Vienna] (Vetmeduni), Universität Ulm - Ulm University [Ulm, Allemagne] |
Rok vydání: | 2009 |
Předmět: |
Male
Biological marker Mitochondrial complex I 75-kDa subunit Early onset schizophrenia Autistic spectrum disorder Gene Expression medicine.disease_cause 0302 clinical medicine ddc:150 Gene expression Developmental and Educational Psychology Psychology Child 0303 health sciences Reverse Transcriptase Polymerase Chain Reaction Psychological Disorders Mental Health Treatment and Prevention General Medicine Psychiatry and Mental health psychische Störungen Behandlung und Prävention Schizophrenia Autism spectrum disorder Biomarker (medicine) Female Clinical psychology medicine.medical_specialty Adolescent Protein subunit behavioral disciplines and activities 03 medical and health sciences Internal medicine mental disorders medicine Humans RNA Messenger Gene 030304 developmental biology Psychiatric Status Rating Scales Electron Transport Complex I Case-control study medicine.disease Endocrinology Psychologie Child Development Disorders Pervasive Case-Control Studies Pediatrics Perinatology and Child Health Biomarkers 030217 neurology & neurosurgery Oxidative stress |
Zdroj: | European Child and Adolescent Psychiatry European Child and Adolescent Psychiatry, Springer Verlag (Germany), 2009, 19 (5), pp.441-448. ⟨10.1007/s00787-009-0074-z⟩ European Child & Adolescent Psychiatry |
ISSN: | 1435-165X 1018-8827 |
Popis: | International audience; Searching for a peripheral biological marker for schizophrenia, we previously reported on elevated mitochondrial complex I 75-kDa subunit mRNA-blood concentrations in early onset schizophrenia (EOS). The aim of this study was to further evaluate the utility of this gene as a potential marker for schizophrenia. Both--schizophrenia and autism--are suggested to be neuronal maldevelopmental disorders with reports of mitochondrial dysfunction and increased oxidative stress. Therefore we have investigated the expression levels of mitochondrial complex I 75-kDa subunit mRNA in whole blood of children with autistic spectrum disorder (ASD) and a group of adolescent acute first-episode EOS patients in comparison to matched controls. We have found that compared to the respective controls only the group of EOS patients--and not the ASD group--showed a significantly altered expression of the complex I 75-kDa subunit mRNA. Although further studies are necessary to test for the specificity of this marker, our findings point to the potential use of the mitochondrial complex I as a biomarker for schizophrenia. |
Databáze: | OpenAIRE |
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