Impact of osmotic pressure on cancer cells in a three-dimensional cellular lattice and cell spheroid
| Autor: | Nadezhda Semenova, Valerij Tuchin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Physics and Astronomy (miscellaneous) Condensed matter physics cell spheroid Quantitative Biology::Tissues and Organs Physics QC1-999 Applied Mathematics Cell Spheroid Statistical and Nonlinear Physics Quantitative Biology::Cell Behavior cellular lattice logistic growth Lattice (module) medicine.anatomical_structure osmotic pressure Cancer cell cancer cells medicine self-organizing Osmotic pressure |
| Zdroj: | Известия высших учебных заведений: Прикладная нелинейная динамика, Vol 29, Iss 4, Pp 559-570 (2021) |
| ISSN: | 0869-6632 |
| Popis: | The purpose of this work is to study the peculiarities of external influence, namely osmotic pressure, on cancer cells. Methods. For this purpose, spatially distributed systems describing the dynamics of a three-dimensional cell lattice, a cell spheroid, and a cell surface have been considered. The studied models are based on the basic principles of hydrodynamics, and their numerical simulation has been performed using a modified Euler method. Results. The paper proposes three-dimensional models to study the dynamics of cancer cells in the epidermal layer of the skin; the models include the possibility of adding additional pressure and changing it with a single parameter. It is shown that it is possible to achieve a slowdown of cancer cell growth in all considered models at certain values of osmotic pressure. |
| Databáze: | OpenAIRE |
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