The iron status of South African blood donors: balancing donor safety and blood demand
Autor: | Ronel Swanevelder, Charlotte Ingram, Karin van den Berg, Deborah K. Glencross, Martin Nieuwoudt, Caroline Hilton, Denise Lawrie |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male medicine.medical_specialty Anemia Iron Immunology Blood Donors 030204 cardiovascular system & hematology Odds Hemoglobins South Africa Young Adult 03 medical and health sciences 0302 clinical medicine Prevalence medicine Humans Immunology and Allergy Young adult biology Obstetrics business.industry Transferrin saturation Hematology Iron deficiency Odds ratio Middle Aged medicine.disease Confidence interval Ferritin Logistic Models Ferritins biology.protein Female business 030215 immunology |
Zdroj: | Transfusion. 59:232-241 |
ISSN: | 1537-2995 0041-1132 |
Popis: | Background Several studies in developed countries have demonstrated high levels of iron deficiency (ID) among blood donors. There is a paucity of data for developing countries where blood shortages remain a major concern. Study design and methods A total of 4412 donors were enrolled in the study. Specimens were collected for full blood count, iron, transferrin saturation, and ferritin assessment. Donor demographics were recorded. ID was indicated by a ferritin level of less than 20 ng/mL for men and less than 12 ng/mL for women. Anemia was defined as hemoglobin levels less than 12.5 g/dL. Regression models for predictors of ID were developed. Results A total of 17.5% of all donors had ID, with 16.3% prevalence in women and 18.6% in men. Low hemoglobin had the highest association with ID (adjusted odds ratio [AOR], 11.078; 95% confidence interval [CI], 7.915-15.505); male donors had twice the odds of ID compared to female donors (AOR, 2.501; 95% CI, 1.964-3.185), while increasing age was associated with lower odds (AOD, 0.965; 95% CI, 0.956-0.975). Among male donors, an interdonation interval of less than 3 months (AOR, 2.679; 95% CI, 1.929-3.720) was associated with ID. Compared to other females combined, colored female donors (AOR, 2.335; 95% CI, 1.310-4.160) had higher odds and black female donors (AOR, 0.559; 95% CI, 0.369-0.845) lower odds of ID. Conclusion ID is common among South African donors; low hemoglobin, gender, ethnicity, and past donation history is independently associated with ID. Recommendations aimed at protecting donor health may increase blood shortages in South Africa. |
Databáze: | OpenAIRE |
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