CD8+ T cells from Theiler’s virus-resistant BALB/cByJ mice downregulate pathogenic virus-specific CD4+ T cells
| Autor: | Stephen D. Miller, Roger W. Melvold, Lia M. Haynes, Carol L. Vanderlugt, Mauro C. Dal Canto |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
CD4-Positive T-Lymphocytes
viruses medicine.medical_treatment T cell Immunology Population Down-Regulation CD8-Positive T-Lymphocytes Biology Virus Mice Theilovirus Cardiovirus Infections Demyelinating disease medicine Animals Immunology and Allergy Cytotoxic T cell Hypersensitivity Delayed education Mice Inbred BALB C education.field_of_study fungi virus diseases Th1 Cells medicine.disease Virology nervous system diseases Cytolysis Cytokine medicine.anatomical_structure Neurology Cytokines Disease Susceptibility Neurology (clinical) human activities Cell Division CD8 Demyelinating Diseases |
| Zdroj: | Journal of Neuroimmunology. 106:43-52 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(00)00212-5 |
| Popis: | Theiler’s murine encephalomyelitis virus (TMEV) is a picornavirus which induces an immune-mediated demyelinating disease in susceptible strains of mice and serves as a relevant animal model for multiple sclerosis. Treatment with low dose irradiation prior to infection with the BeAn strain of TMEV renders the genetically resistant BALB/cByJ (C/cByJ) mice susceptible to disease. Previous studies have shown that disease resistance in the C/cByJ is mediated by a ‘regulatory’ CD8 + T cell population, which does not appear to function via a cytolytic mechanism. We show here that TMEV-specific CD4 + T cell blasts transferred into susceptible, irradiated C/cByJ accelerate clinical disease and enhance TMEV-specific DTH and proliferation in these animals. Significantly, CD8 + cells from infected, resistant C/cByJ mice specifically downregulate the in vivo disease potentiation and diminish virus specific DTH, and proliferative and pro-inflammatory cytokine responses (IFNγ and IL-2) in recipients of TMEV-specific CD4 + T cell blasts. These results indicate that TMEV infection of resistant C/cByJ mice induces a radiosensitive population of regulatory CD8 + T cells which actively downregulate inherent Th1 responses which have disease initiating potential. |
| Databáze: | OpenAIRE |
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